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Associations between BNP levels and outcome were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> at the onset of ALI was 155 (\u00b174) and BNP values ranged from 5 to 2,060\u2009pg\/ml with a mean of 109 (\u00b1311). BNP levels were inversely correlated with ventilator\u2010free days (Spearman rho \u22120.30, <jats:italic>P<\/jats:italic>\u2009=\u20090.04), and positively correlated with exhaled tidal volume (Spearman rho 0.44, <jats:italic>P<\/jats:italic>\u2009=\u20090.02). BNP levels were higher in patients receiving inotropic support (n\u2009=\u200912) than patients not receiving inotropic support (n\u2009=\u200933, <jats:italic>P<\/jats:italic>\u2009=\u20090.02). BNP levels were correlated with PRISM III scores (Spearman rho 0.55, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and PELOD scores (Spearman rho 0.4, <jats:italic>P<\/jats:italic>\u2009=\u20090.006). Mortality for the cohort was 15%. BNP levels were higher in non\u2010survivors (n\u2009=\u20097) than survivors (n\u2009=\u200941, <jats:italic>P<\/jats:italic>\u2009=\u20090.055).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>BNP levels are elevated in children with ALI\/ARDS early in the disease course, and increased levels are associated with worse clinical outcome. Pediatr Pulmonol. 2009; 44:1118\u20131124. \u00a92009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.21111","type":"journal-article","created":{"date-parts":[[2009,10,14]],"date-time":"2009-10-14T19:53:46Z","timestamp":1255550026000},"page":"1118-1124","source":"Crossref","is-referenced-by-count":14,"title":["Early elevations in B\u2010type natriuretic peptide levels are associated with poor clinical outcomes in pediatric acute lung injury"],"prefix":"10.1002","volume":"44","author":[{"given":"Bhupinder","family":"Reel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter 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