{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T10:29:08Z","timestamp":1782815348485,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2009,11,12]],"date-time":"2009-11-12T00:00:00Z","timestamp":1257984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify cystic fibrosis (CF) patients with a history of meconium ileus (MI) and to compare long\u2010term outcome of these patients with CF patients without MI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>370 CF patients who were treated at the Munich CF centre in 2006, mean age 17.1 years (range: 0\u201348), were classified with regard to a history of MI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective chart analysis regarding history of MI, age, and lung function and first detection of <jats:italic>Pseudomonas aeruginosa<\/jats:italic> as the primary outcome variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 60 patients with MI (16.2% of all patients with a mean age of 16.2\u2009\u00b1\u20099 years (0\u201341) who did not differ in age from patients without MI (17.3\u2009\u00b1\u200910; 0\u201348), whereas the mean age of CF diagnosis was different (0.4 vs. 21.8 months, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Cross sectional analysis of best Forced expiratory volume (FEV% predicted) in 2006 was not different between patients with MI (89\u2009\u00b1\u200923%, 17\u2013134) and those without (88\u2009\u00b1\u200927%, 21\u2013148, <jats:italic>P<\/jats:italic>\u2009=\u20090.73). Longitudinal analysis using FEV1 values of more than 9,000 lung function tests also showed no difference in FEV1 although first detection of <jats:italic>P. aeruginosa<\/jats:italic> in patients with MI was significantly earlier.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MI was associated with hospitalization, surgery, and early infection with <jats:italic>P. aeruginosa<\/jats:italic>. However, the long\u2010term outcome of CF patients with or without MI was the same. This finding might be explained by the considerably earlier CF diagnosis in CF patients with MI including the benefit of an early initiation of appropriate CF therapy. Pediatr Pulmonol. 2009; 44:1201\u20131206. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.21119","type":"journal-article","created":{"date-parts":[[2009,11,12]],"date-time":"2009-11-12T18:21:06Z","timestamp":1258050066000},"page":"1201-1206","source":"Crossref","is-referenced-by-count":21,"title":["Long\u2010term pulmonary outcome after meconium ileus in cystic fibrosis"],"prefix":"10.1002","volume":"44","author":[{"given":"Matthias","family":"Kappler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Feilcke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Schr\u00f6ter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Kraxner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Griese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,11,12]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"833","article-title":"A review of 164 children with meconium ileus seen at the Children's Hospital Medical Center","volume":"37","author":"Donnison AB","year":"1966","journal-title":"Boston Pediatr"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80134-9"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(81)80027-3"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1542\/peds.9.3.304","article-title":"Chemical comparison of normal meconium and meconium from a patient with meconium ileus","volume":"9","author":"Buchanan DJ","year":"1952","journal-title":"Pediatrics"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5672.718"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)90210-X"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.117671"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.08.014"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.08.012"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","unstructured":"SouthernKW MerelleMME Dankert\u2010RoelseJE NagelkerkeA.Newborn screening for cystic fibrosis.Cochrane Database of Systematic Reviews2009.","DOI":"10.1002\/14651858.CD001402.pub2"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199202000-00014"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1989.01410070095019"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2005.06.049"},{"key":"e_1_2_1_15_2","first-page":"699","article-title":"Meconium ileus: a fifteen\u2010year experience with forty\u2010two neonates","volume":"102","author":"Caniano DA","year":"1987","journal-title":"Surgery"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20092"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.05.014"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.049536"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001120170107"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-195703000-00017"},{"key":"e_1_2_1_21_2","first-page":"1","article-title":"Physical growth of Swiss children from birth to 20 years of age. First Zurich longitudinal study of growth and development","volume":"52","author":"Prader A","year":"1989","journal-title":"Helv Paediatr Acta Suppl"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.1.53"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.101.4.e7"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950120306"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.21119","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.21119","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.21119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T11:00:06Z","timestamp":1699959606000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.21119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,12]]},"references-count":23,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["10.1002\/ppul.21119"],"URL":"https:\/\/doi.org\/10.1002\/ppul.21119","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,12]]}}}