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Animals received 200\u2009mg\/kg of porcine natural surfactant or 200\u2009mg\/kg of natural surfactant combined with 400 or 800\u2009\u00b5g\/kg of beclomethasone. Lung tissue oxidation was studied by measuring total hydroperoxide (TH), advanced oxidation protein products (AOPP), and non\u2010protein bound iron (NPBI) in bronchial aspirate samples. In addition, lung mechanics was evaluated. TH was lower in the groups treated with surfactant plus 400 or 800\u2009\u00b5g\/kg of beclomethasone than in the surfactant group; AOPP was lower in the group treated with surfactant plus 800\u2009\u00b5g\/kg of beclomethasone than in the other groups; NPBI was similar in all groups. Surfactant treatment was followed by a sustained improvement of tidal volume (TV) and airway resistance, while dynamic compliance did not vary. However, the mean airway pressure needed to obtain similar values of TV was lower in the group treated with surfactant plus 800\u2009\u00b5g\/kg of beclomethasone than in other groups. We concluded that natural surfactant combined with beclomethasone at 800\u2009\u00b5g\/kg is effective in reducing the oxidative lung stress and improving the respiratory function in an animal model of RDS. Pediatr Pulmonol. 2009; 44:1159\u20131167. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.21145","type":"journal-article","created":{"date-parts":[[2009,11,12]],"date-time":"2009-11-12T18:21:43Z","timestamp":1258050103000},"page":"1159-1167","source":"Crossref","is-referenced-by-count":28,"title":["Natural surfactant combined with beclomethasone decreases oxidative lung injury in the preterm 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