{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:24:30Z","timestamp":1773296670716,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,5,17]],"date-time":"2010-05-17T00:00:00Z","timestamp":1274054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine and validate a cut\u2010off value for bronchodilation using the interrupter resistance (Rint) in preschool children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Rint was measured in 60 healthy children (age range 2.7\u20136.4 years) before and after salbutamol inhalation (200\u2009\u00b5g). Four potential methods for assessing BDR were evaluated: percent change from baseline, percent change of predicted values, absolute change in Rint, and change in Z\u2010score. These cut\u2010off values, determined as the fifth percentile of the healthy group, were applied to children referred for the assessment of recurrent wheezing, classified on the basis of acute symptoms and\/or abnormal chest examination into symptomatic (n\u2009=\u200960, age range 2.9\u20136.1 years) and asymptomatic (n\u2009=\u200960, age range 2.5\u20135.7 years) groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cut\u2010off values for bronchodilation calculated in healthy children were: \u221232% baseline; \u221233% predicted; \u22120.26\u2009kPa L<jats:sup>\u22121<\/jats:sup> sec; and \u22121.25 Z\u2010scores. Assessing BDR in children with a history of wheezing by either a decrease in absolute Rint or a decrease in Z\u2010score gave sensitivity, specificity, negative predictive value, and positive predictive value all &gt;80% for detecting children with current respiratory symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both a decrease in Rint \u22650.26\u2009kPa L<jats:sup>\u22121<\/jats:sup> sec and a decrease in Z\u2010score of \u22651.25 are appropriate for assessing BDR in preschool children with a history of recurrent wheezing. As Z\u2010score is a more general solution, we recommend using a change in Z\u2010score to determine BDR in preschool children. Further longitudinal studies will be required to determine the clinical utility of measuring BDR in managing lung disease in such children. Pediatr Pulmonol. 2010; 45:633\u2013638. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.21210","type":"journal-article","created":{"date-parts":[[2010,5,17]],"date-time":"2010-05-17T19:57:53Z","timestamp":1274126273000},"page":"633-638","source":"Crossref","is-referenced-by-count":26,"title":["Assessment and validation of bronchodilation using the interrupter technique in preschool children"],"prefix":"10.1002","volume":"45","author":[{"given":"Laura","family":"Mele","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter D.","family":"Sly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Calogero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Bernardini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elio","family":"Novembre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Azzari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"de Martino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,6,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200605-642ST"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199805)25:5<322::AID-PPUL6>3.0.CO;2-K"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2011082"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.6.2005076"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.13d16.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.9.761"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.4.344"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.56.9.691"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200303-449OC"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.6.2010153"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200205-421OC"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200303-347OC"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.4.2006119"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2007.07.005"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.13d16.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.6.2005076"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90402-O"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501193320301"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.21210","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.21210","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.21210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T17:06:59Z","timestamp":1700586419000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.21210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,23]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.1002\/ppul.21210"],"URL":"https:\/\/doi.org\/10.1002\/ppul.21210","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,23]]}}}