{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:45:41Z","timestamp":1758815141940},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2010,8,17]],"date-time":"2010-08-17T00:00:00Z","timestamp":1282003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Positional cloning and candidate gene studies in different Caucasian populations identified the gene encoding plant homeodomain zinc finger protein 11 (<jats:italic>PHF11<\/jats:italic>) to be associated with asthma and eczema. Microarray analysis also confirmed increased <jats:italic>PHF11<\/jats:italic> expression in type 1 T\u2010helper lymphocytes. However, such disease associations are unclear in Asian subjects. This case\u2013control genetic association study investigated the relationship between asthma and eczema phenotypes and tagging single\u2010nucleotide polymorphisms (SNPs) of <jats:italic>PHF11<\/jats:italic> in Hong Kong Chinese children. Three hundred and nineteen asthmatic children and 236 children with eczema were recruited from hospital clinics and 445 children without any history of allergic disease were recruited as controls from local schools and hospitals. Atopy was defined by the presence of allergen\u2010specific IgE in plasma or positive skin prick tests with wheal \u22653\u2009mm larger than negative control. Lung function of asthmatics was evaluated by pre\u2010bronchodilator spirometry. Ten <jats:italic>PHF11<\/jats:italic> SNPs were genotyped by multiplex SNaPshot\u2122 assay. Genotyping call rates were 100% for all SNPs, which also followed Hardy\u2013Weinberg equilibrium. These SNPs were tightly linked in one haplotype block (D\u2032\u2009\u2265\u20090.95 for nearly all SNP pairs). Physician\u2010diagnosed asthma was weakly associated with <jats:italic>PHF11<\/jats:italic> +20860 and +22818 (<jats:italic>P<\/jats:italic>\u2009=\u20090.032 for both). Atopy was also associated with <jats:italic>PHF11<\/jats:italic> +22398 (<jats:italic>P<\/jats:italic>\u2009=\u20090.029). However, none of the <jats:italic>PHF11<\/jats:italic> SNPs was associated with eczema diagnosis and plasma total IgE and spirometric parameters in our patients. Our findings do not support <jats:italic>PHF11<\/jats:italic> to be a major candidate gene for asthma, eczema and aeroallergen sensitization in Chinese children. Pediatr. Pulmonol. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.21242","type":"journal-article","created":{"date-parts":[[2010,8,17]],"date-time":"2010-08-17T19:29:56Z","timestamp":1282073396000},"page":"890-897","source":"Crossref","is-referenced-by-count":1,"title":["<i>PHF11<\/i> is not a major candidate gene for asthma or eczema in Chinese children"],"prefix":"10.1002","volume":"45","author":[{"given":"Hing Y.","family":"Sy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris H.S.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellis K.L.","family":"Hon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice P.S.","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson L.S.","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung Y.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary W.K.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary M.Y.","family":"Waye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher W.K.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana C.N.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting F.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,8,17]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90280-5"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.04.039"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1166"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200704-592OC"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.02.028"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364169"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.102053"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.108985"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/136.1.225"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2340\/00015555924447","article-title":"Diagnostic features of atopic dermatitis","volume":"2","author":"Hanifin JM","year":"1980","journal-title":"Acta Derm Venereol (Stockh)"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000189196"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.02064.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.09.031"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01639.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02799.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2008.01034.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.3.7663792"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.2.9905057"},{"key":"e_1_2_6_20_2","unstructured":"International HapMap Project.Accessed on 10 July 2009 athttp:\/\/www.hapmap.org\/cgi\u2010perl\/gbrowse\/hapmap24_B36."},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01873.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2008.00835.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/383247a0"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.108985"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1159\/000235545"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.03.048"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364279"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btf869"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1086\/518312"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.20182"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.21242","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.21242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T12:35:37Z","timestamp":1697632537000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.21242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,17]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["10.1002\/ppul.21242"],"URL":"https:\/\/doi.org\/10.1002\/ppul.21242","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,17]]}}}