{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:06:10Z","timestamp":1760983570873},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 3\u2010year\u2010old boy with failure to thrive and severe adenotonsillar hypertrophy with a clinical presentation of prolonged obstructive sleep apnea (OSA), was referred to the emergency room due to severe respiratory distress and anasarca. Echocardiography revealed right heart failure, a cystic lesion in the right ventricle and severe pulmonary hypertension. <jats:sc>D<\/jats:sc>\u2010dimer was elevated but spiral computerized tomography (CT) and lung scan did not show any perfusion defects. Excision of the cardiac lesion during open\u2010heart surgery, lung biopsy, and adenotonsillectomy were performed. Pathological examination showed an intracadiac organized thrombus and eccentric intimal fibrosis of the pulmonary arteries\u2014which is a pathognomonic of pulmonary arterial microemboli. Brain CT revealed vein thrombosis of the left sigmoid sinus. Blood tests for inherited thrombophilia were normal. Today, 5 years after adenotonsillectomy, the child is normally developed, completely asymptomatic, free of any medications, and has a normal echocardiography. This case report may indicate that prolonged OSA can be a procoagulant state which can cause severe cardiovascular morbidity in children. Pediatr. Pulmonol. 2010; 45:836\u2013839. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.21256","type":"journal-article","created":{"date-parts":[[2010,7,6]],"date-time":"2010-07-06T18:13:30Z","timestamp":1278440010000},"page":"836-839","source":"Crossref","is-referenced-by-count":6,"title":["Cardiac, lung, and brain thrombosis in a child with obstructive sleep apnea"],"prefix":"10.1002","volume":"45","author":[{"given":"Shlomo","family":"Cohen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaim","family":"Springer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeev","family":"Perles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin Z.","family":"Koplewitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avraham","family":"Avital","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoshana","family":"Revel\u2010Vilk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,7,16]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-996096"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.5.1251.1251"},{"key":"e_1_2_4_4_2","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1542\/peds.96.5.939","article-title":"Neonatal thrombosis: report of a prospective Canadian and international registry","volume":"96","author":"Schmidt B","year":"1995","journal-title":"Pediatrics"},{"key":"e_1_2_4_5_2","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1055\/s-0038-1660322","article-title":"Thrombosen in Kindesalter","volume":"12","author":"Sutor AH","year":"1992","journal-title":"Haemostaseologie"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02282879"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-001-0066-3"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.4.e69"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.018739"},{"key":"e_1_2_4_10_2","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1055\/s-0037-1615353","article-title":"Association of fibrinogen, factor VII and PAI\u20101 with baseline finding among 10,500 male participants in a prospective study of myocardial infarction\u2014The PRIME Study. 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