{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T20:24:49Z","timestamp":1771532689396,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,5,17]],"date-time":"2010-05-17T00:00:00Z","timestamp":1274054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Partial liquid ventilation (PLV) with perfluorocarbons (PFC) seems not superior to conventional ventilation clinically. We hypothesized that a combination of continuous tracheal gas insufflation (TGI) with protective strategy of PLV (low dose of PFC, low inflation pressure, moderate inhalation of oxygen and moderate anesthesia) would improve cardiopulmonary function in acute lung injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010four healthy juvenile piglets were anesthetized and mechanically ventilated at PEEP of 2\u2009cmH<jats:sub>2<\/jats:sub>O with a peak inspiratory pressure of 10\u2009cmH<jats:sub>2<\/jats:sub>O and FIO<jats:sub>2<\/jats:sub> of 0.4. The piglets were challenged with lipopolysaccharide and randomly assigned to four groups (n\u2009=\u20096 each): (1) mechanical ventilation alone (MV); (2) PLV with perfluorodecalin (10\u2009ml\/kg); (3) TGI with continuous airway flow 2\u2009L\/min; and (4) combination of PLV and TGI. The outcome was assessed functionally and histologically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All treatments except MV improved pH, PaO<jats:sub>2<\/jats:sub>\/FIO<jats:sub>2<\/jats:sub>, PaCO<jats:sub>2<\/jats:sub>, ventilation efficacy index (VEI) and tidal volume. Both PLV\u2010associated treatments also improved heart rate, respiratory rate, pulse contour cardiac output, systemic vascular resistance, dynamic lung compliance, mean airway resistance and mean airway pressure. The combination group resulted in higher PaO<jats:sub>2<\/jats:sub>\/FIO<jats:sub>2<\/jats:sub>, VEI and a better lung histology score than any other treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The new protective strategy may provide a better treatment for sepsis\u2010induced acute lung injury. Pediatr Pulmonol. 2010; 45:700\u2013707. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.21257","type":"journal-article","created":{"date-parts":[[2010,5,17]],"date-time":"2010-05-17T19:57:44Z","timestamp":1274126264000},"page":"700-707","source":"Crossref","is-referenced-by-count":4,"title":["Tracheal gas insufflation with partial liquid ventilation to treat LPS\u2010induced acute lung injury in juvenile 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