{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T10:29:06Z","timestamp":1782815346406,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,7,29]],"date-time":"2010-07-29T00:00:00Z","timestamp":1280361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"none reported"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It is a matter of debate as to what extent the long\u2010term outcome of cystic fibrosis (CF) is affected by presenting with meconium ileus (MI). We compared long\u2010term clinical outcomes of CF children who presented with MI, to those presenting with other symptoms (non\u2010MI) in an era of non new\u2010born\u2010screening (NBS).<\/jats:p><jats:p>We collected annual lung function data between the ages of 8\u201315 years in terms of percent predicted first second forced expired volume (FEV1%pr), percent predicted forced vital capacity (FVC%pr), and between the ages of 2\u201315 years annual height and weight Z\u2010scores (HtZ and WtZ respectively) for children attending the Royal Brompton Hospital CF clinic. To be included in the study, subjects had to have at least five pulmonary function tests and five anthropometric measurements recorded over this period.<\/jats:p><jats:p>Thirty\u2010eight MI and 76 non\u2010MI subjects were compared. There were no significant differences in genotype, sex, chronic <jats:italic>Pseudomonas<\/jats:italic> infection, or pancreatic enzyme use between the two groups. The median age of diagnosis was 1 day (MI) versus 7 months (non\u2010MI). There was a decline in spirometry and anthropometric variables over the study period for both MI and non\u2010MI groups apart from WtZ score in the non\u2010MI group. Mixed model analysis adjusting for potential confounders including genotype, pancreatic status, sex, chronic <jats:italic>Pseudomonas aeruginosa<\/jats:italic> lung infection, and age of diagnosis revealed no difference between the two groups in terms of lung function and growth during the time period of the study, however there was a non\u2010significant trend for subjects presenting with MI to do better in all four parameters.<\/jats:p><jats:p>We conclude that babies presenting with MI have no worse long\u2010term outcome than those presenting symptomatically later in infancy, despite having undergone invasive procedures in the newborn period. This underscores the importance of early diagnosis and treatment in CF. Pediatr Pulmonol. 2010; 45:951\u2013958. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.21271","type":"journal-article","created":{"date-parts":[[2010,7,29]],"date-time":"2010-07-29T15:31:41Z","timestamp":1280417501000},"page":"951-958","source":"Crossref","is-referenced-by-count":28,"title":["Does presenting with meconium ileus affect the prognosis of children with cystic fibrosis?"],"prefix":"10.1002","volume":"45","author":[{"given":"Jo\u2010Anne","family":"Johnson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Bush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Buchdahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,7,29]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0011-3840(94)90040-X"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003830050341"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.67.10_Spec_No.1204"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20092"},{"key":"e_1_2_6_6_2","first-page":"S30","article-title":"Longitudinal pulmonary status of cystic fibrosis children with meconium ileus","volume":"147","author":"Li Z","year":"2005","journal-title":"Pediatrics"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh083"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.1.53"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.05.014"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80134-9"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21119"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7129.404"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.48.8.794"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.41.220.613"},{"key":"e_1_2_6_15_2","unstructured":"GoreMS AltmanDG.Statistics in Practice. 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