{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:15:57Z","timestamp":1759540557267},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2010,10,26]],"date-time":"2010-10-26T00:00:00Z","timestamp":1288051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Data regarding the role of inhaled colistin in critically ill pediatric patients without cystic fibrosis are scarce. Three children (one female), admitted to the intensive care unit (ICU) of a tertiary\u2010care pediatric hospital in Athens, Greece, during 2004\u20132009 received inhaled colistin as monotherapy for tracheobronchitis (two children), and as adjunctive therapy for necrotizing pneumonia (one child). Colistin susceptible <jats:italic>Acinetobacter baumannii<\/jats:italic> and <jats:italic>Pseudomonas aeruginosa<\/jats:italic> were isolated from the cases' bronchial secretions specimens. All three children received inhaled colistin at a dosage of 75\u2009mg diluted in 3\u2009ml of normal saline twice daily (1,875,000\u2009IU of colistin daily), for a duration of 25, 32, and 15 days, respectively. All three children recovered from the infections. Also, a gradual reduction, and finally total elimination of the microbial load in bronchial secretions was observed during inhaled colistin treatment in the reported cases. All three cases were discharged from the ICU. No bronchoconstriction or any other type of toxicity of colistin was observed. In conclusion, inhaled colistin was effective and safe for the treatment of two children with tracheobronchitis, and one child with necrotizing pneumonia. Further studies are needed to clarify further the role of inhaled colistin in pediatric critically ill patients without cystic fibrosis. Pediatr Pulmonol. 2010;45:1135\u20131140. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.21302","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T13:36:03Z","timestamp":1279892163000},"page":"1135-1140","source":"Crossref","is-referenced-by-count":20,"title":["Inhaled colistin for the treatment of tracheobronchitis and pneumonia in critically ill children without cystic fibrosis"],"prefix":"10.1002","volume":"45","author":[{"given":"Matthew E.","family":"Falagas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgia","family":"Sideri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioanna P.","family":"Korbila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evridiki 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