{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T17:15:56Z","timestamp":1771002956499,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,8,17]],"date-time":"2010-08-17T00:00:00Z","timestamp":1282003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is minimal literature available on the long\u2010term outcome of pediatric non\u2010cystic fibrosis (CF) bronchiectasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To document 5\u2010year outcomes of children with chest computerized tomography (CT) scan diagnosed bronchiectasis from a tertiary New Zealand (NZ) respiratory clinic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Review of a clinical database identified 91 children. Demographics, clinical data, lung function, chest X\u2010ray (CXR), sputum, presumed etiology, admission data, and the NZ deprivation index (NZDep) were collected. Univariate and multivariate regression were used to correlate clinical findings with lung function data and CXR scores using the Brasfield Scoring System.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 91 children, 53 (59%) were Pacific Island, 22 (24%) Maori, 14 (15%) European, and 2 (2%) Other. The median follow\u2010up period was 6.7 years (range 5.0\u201315.3 years) and median age at diagnosis was 7.3 years (range 11 months\u201316 years). Lung function data (n\u2009=\u200964) showed a mean decline of \u22121.6% predicted\/year. In 30 children lung function declined (mean FEV<jats:sub>1<\/jats:sub> \u22124.4% predicted\/year, range 1\u201317%), remained stable in 13 and improved in 21 children (mean FEV<jats:sub>1<\/jats:sub> of +3% predicted\/year, range 1\u201315%). Reduced lung function was associated with male gender, chronic <jats:italic>Haemophilus influenzae<\/jats:italic> infection, longevity of disease, and Maori and Pacific Island ethnicity. There was a significant correlation with FEV<jats:sub>1<\/jats:sub> and CXR score at beginning (n\u2009=\u200947, r\u2009=\u20090.45, <jats:italic>P<\/jats:italic>\u2009=\u20090.001) and end (n\u2009=\u200926, r\u2009=\u20090.59, <jats:italic>P<\/jats:italic>\u2009=\u20090.002) of the follow\u2010up period. The only variable consistently related to CXR score was chronic <jats:italic>Haemophilus influenzae<\/jats:italic> infection occurring in 27 (30%) (r<jats:sup>2<\/jats:sup>\u2009=\u20090.52, <jats:italic>P<\/jats:italic>\u2009=\u2009&lt;0.0001). Only four children were chronically infected with <jats:italic>Pseudomonas<\/jats:italic> species. Six children died.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our experience despite management in a tertiary multidisciplinary bronchiectasis clinic, progression of lung disease continues in a group of children and young adults. Pediatr. Pulmonol. 2011; 46:131\u2013138. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.21331","type":"journal-article","created":{"date-parts":[[2010,8,17]],"date-time":"2010-08-17T19:27:20Z","timestamp":1282073240000},"page":"131-138","source":"Crossref","is-referenced-by-count":36,"title":["Do New Zealand children with non\u2010cystic fibrosis bronchiectasis show disease progression?"],"prefix":"10.1002","volume":"46","author":[{"given":"Karen A.","family":"Munro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter W.","family":"Reed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Joyce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Perry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Twiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine A.","family":"Byrnes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,8,17]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.066472"},{"key":"e_1_2_6_3_2","first-page":"276","article-title":"The course of childhood bronchiectasis: a case report and considerations of hospital use","volume":"57","author":"Saynajakangas O","year":"1998","journal-title":"Int J Circumpolar Health"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20783"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21020"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2003.00101.x"},{"key":"e_1_2_6_7_2","volume-title":"The health of Pacific Islands people in New Zealand","author":"Bathgate M","year":"1994"},{"key":"e_1_2_6_8_2","unstructured":"CraigE.Report on the Health of Pacific Children and Young People in New Zealand. 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