{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:33:04Z","timestamp":1784043184837,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,12,30]],"date-time":"2010-12-30T00:00:00Z","timestamp":1293667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Kuopio University Hospital, The National Graduate School of Clinical Investigation, The National Foundation for Pediatric Research in Finland, Tampere Tuberculosis Foundation."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Recently, obesity has been connected with wheezing, asthma and reduced lung function. Most previous studies have been cross\u2010sectional. The aim of the present follow\u2010up study was to evaluate the association of preceding or current overweight or obesity with lung function at early and late school age after early childhood wheezing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>From the 100 children hospitalized for infection associated wheezing at &lt;24 months of age, 83 attended the control visit at 4.0 years, 82 at 7.2 years and 81 at 12.3 years of age. Flow\u2010volume spirometry was performed in 79 children at 7.2 years and in 80 children at 12.3 years of age. The weight status was assessed by calculating body mass index (BMI) at all visits. Age\u2010 and gender\u2010specific BMI standard deviation scores (BMI\u2013SDS) of &gt;1.3\u2009SD and &gt;2.0\u2009SD were defined to mean overweight and obesity, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overweight at both 7.2 and 12.3 years of age was associated with decreased FEV<jats:sub>1<\/jats:sub>\/FVC (forced expiratory volume in 1\u2009sec\/forced vital capacity). Overweight and obesity at 7.2 years of age were associated with decreased FEV<jats:sub>1<\/jats:sub>\/FVC and MEF<jats:sub>50<\/jats:sub> (maximal expiratory flow at 50% of FVC) at 12.3 years of age. The results were similar by continuous and categorized analyses, being robust to adjustments for viral findings during early childhood wheezing and asthma maintenance medication at school age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overweight and obesity are significant risk factors for reduced lung function at school age after early childhood wheezing. Thus, early\u2010life wheezers should avoid excessive weight gain during childhood. Pediatr. Pulmonol. 2011; 46:435\u2013441. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.21386","type":"journal-article","created":{"date-parts":[[2010,12,30]],"date-time":"2010-12-30T17:46:21Z","timestamp":1293731181000},"page":"435-441","source":"Crossref","is-referenced-by-count":15,"title":["Lung function and overweight in school aged children after early childhood wheezing"],"prefix":"10.1002","volume":"46","author":[{"given":"Virpi","family":"Sidoroff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Hyv\u00e4rinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eija","family":"Piippo\u2010Savolainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Korppi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,30]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.11.050"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.2.315"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-789X.2003.00116.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.12.1031"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1081\/JAS-120026097"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2002.001529"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803571"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2008.00803.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2007.00686.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg175"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10376"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803145"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01872.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.56.1.4"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200405-623OC"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01260.2007"},{"key":"e_1_2_6_18_2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/00365518209168377","article-title":"Spirometric studies in non\u2010smoking healthy adults","volume":"159","author":"Viljanen A","year":"1982","journal-title":"Scand J Clin Lab Invest"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20995"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.072223"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.086819"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-112-11-828"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.3.827"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.13.1477"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7238.827"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.88.4.361"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21091"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.5.512"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.6.1406"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.2002.02091.x"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20273"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1996.02170300066013"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199808)26:2<113::AID-PPUL7>3.0.CO;2-N"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.33"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000143642.72480.53"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2005.tb01884.x"},{"key":"e_1_2_6_37_2","unstructured":"Northwest Institute for Bio\u2010Health Informatics.Child obesity calculator using British 1990 growth reference data.http:\/\/www.phsim.man.ac.uk\/. Accessed January 18 2007."},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.73.1.25"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.73.1.17"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19980228)17:4<407::AID-SIM742>3.0.CO;2-L"},{"key":"e_1_2_6_41_2","first-page":"45","article-title":"The LMS method for constructing normalized growth standards","volume":"44","author":"Cole TJ","year":"1990","journal-title":"Eur J Clin Nutr"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7244.1240"},{"key":"e_1_2_6_43_2","first-page":"395","article-title":"Reference values for flow\u2010volume spirometry and peak expiratory flow rates in healthy Finnish children","volume":"5","author":"Koillinen H","year":"1998","journal-title":"Finn Med J"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2007.00458.x"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2008.02620.x"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801928"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01597.x"},{"key":"e_1_2_6_48_2","first-page":"156","article-title":"Obesity among Children residing in Mexico City and its impact on lung function: A comparison with Mexican\u2010Americans","author":"Peres\u2010Padilla R","year":"2006","journal-title":"Arch Med Res"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199709)24:3<187::AID-PPUL4>3.0.CO;2-K"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.12.1036"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802998"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.21386","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.21386","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.21386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T08:58:27Z","timestamp":1697619507000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.21386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,30]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["10.1002\/ppul.21386"],"URL":"https:\/\/doi.org\/10.1002\/ppul.21386","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,30]]}}}