{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:08:52Z","timestamp":1789880932326,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,12,30]],"date-time":"2010-12-30T00:00:00Z","timestamp":1293667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"none reported"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mechanical ventilation (MV) strategies are continuously evolving in an effort to minimize adverse events. The objective of this study was to determine the complications associated with MV in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective observational study. Over a period of 10 consecutive months, 150 patients (median age 0.8 years, IQR 4.4, 59% male) were enrolled in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median duration of MV was 3.1 days (IQR 3.9). A total of 85 complications were observed in 60 (40%) patients (114 complications per 1,000 ventilation days). 16.7% of patients developed atelectasis, 13.3% post\u2010extubation stridor, 9.3% failed extubation, 2.0% pneumothorax, 3.3% accidental extubation, 2.7% nasal or perioral tissue damage and 1.9% ventilator associated pneumonia. Atelectasis occurred most often in the left lower lobe (36%) or in the right upper lobe (26%). The incidence of atelectasis in children &lt;1 year of age was 12% (31 episodes per 1,000 days of ventilation) compared to 18% (57 episodes per 1,000 days of ventilation) in children \u22651 year of age (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Patients that failed extubation were ventilated for a median of 8.5 (IQR 8.8) days compared to 2.9 days (IQR, 3.8) in patients that were successfully extubated (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). The absence of an air leak prior to extubation did not correlate with failed extubation. Accidental extubation was limited to orally intubated patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MV complications occurred in 40% of patients and most often consisted of atelectasis and post\u2010extubation stridor. Further studies are needed to examine associated risk factors and strategies to reduce their occurrence. Pediatr Pulmonol. 2011; 46:452\u2013457. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.21389","type":"journal-article","created":{"date-parts":[[2010,12,30]],"date-time":"2010-12-30T17:45:50Z","timestamp":1293731150000},"page":"452-457","source":"Crossref","is-referenced-by-count":89,"title":["Complications of mechanical ventilation in the pediatric population"],"prefix":"10.1002","volume":"46","author":[{"given":"Tania","family":"Principi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas D.","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin C.","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami Al","family":"Farsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose F.","family":"Carrelas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Maurice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alik","family":"Kornecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,30]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"873","article-title":"Complications of mechanical ventilation in a children's hospital multidisciplinary intensive care unit","volume":"35","author":"Benjamin PK","year":"1990","journal-title":"Respir Care"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1078-5337(05)70069-1"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199202000-00008"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(74)90440-9"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.5.758"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.3.897"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000154922.65189.48"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000094228.90557.85"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000269390.48450.AF"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.03.019"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00130478-200301000-00003"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-0207"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199808)26:2<125::AID-PPUL9>3.0.CO;2-L"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3181849901"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/prrv.2000.0059"},{"key":"e_1_2_5_17_2","unstructured":"CDC.NNIS criteria for determining nosocomial pneumonia. 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