{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:33:17Z","timestamp":1790854397554,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,2,18]],"date-time":"2011-02-18T00:00:00Z","timestamp":1297987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"G. Bierich, managing director, Interfinanz, Duesseldorf, Germany"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Pulmonary angiogenesis is a prerequisite for lung development. Angiopoietin\u20102 (Ang2) destabilizes endothelial cells through its endothelial receptor TIE\u20102, enabling vascular sprouting. Ang1 stabilizes new blood vessels. Soluble TIE\u20102 (sTIE\u20102) modulates these effects. We hypothesized that histological funisitis is associated with alterations of Ang2 in airways and of the systemic angiopoietin\u2010TIE\u20102 homeostasis in very low birth weight (VLBW) infants, contributing to pulmonary morbidity and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We measured Ang2 in tracheobronchial aspirate fluid (TAF) of 42 VLBW &lt;30 weeks of gestation from day 1 through 15 and Ang1, Ang2, and sTIE\u20102 in umbilical cord serum of 28 infants by enzyme\u2010linked immunosorbent assay. Histological examination distinguished three groups: funisitis, chorioamnionitis, and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Funisitis was associated with lower Ang2 values in TAF but not with changes of Ang1, Ang2, and sTIE\u20102 in umbilical cord serum. Infants who developed bronchopulmonary dysplasia (BPD) or died had a persistently decreased ratio of previously measured Ang1 to Ang2 in TAF on days 1\u20135 and increased cord serum concentrations of sTIE\u20102. Moderate BPD\/death was associated with an increase of Ang2 in TAF on day 10 and decreased Ang1\/Ang2 ratio from day 3\u201315. Small for gestational age (SGA) infants had increased Ang2 in TAF on day 1\u20137 and a lower Ang1\/Ang2 ratio on days 5\u20137.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The predominance of Ang2 in airway fluid of infants with BPD\/death and SGA infants suggests a link between disrupted placental and fetal pulmonary angiogenesis. Histological funisitis with reduced Ang2 in TAF was of minor relevance for outcome in our cohort. Pediatr. 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