{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:10:49Z","timestamp":1788869449627,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,4,25]],"date-time":"2011-04-25T00:00:00Z","timestamp":1303689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Richard W. 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Steady\u2010state levels of SP\u2010A protein and mRNA and SP\u2010B mRNA in human bronchiolar (NCI\u2010H441) and mouse alveolar (MLE15) epithelial cells were reduced in a dose\u2010dependent manner 18\u2009hr after exposure to infant formula. SP\u2010A mRNA levels remained reduced 42\u2009hr after exposure, but SP\u2010B mRNA levels increased 10\u2010fold. Neither soy formula nor non\u2010fat dry milk affected steady\u2010state SP\u2010A and SP\u2010B mRNA levels; suggesting a role of a component of infant formula derived from cow milk. These results indicate that infant formula has a direct, dose\u2010dependent effect to reduce surfactant protein gene expression. Ultimately, milk aspiration may potentially result in a reduced capacity of the lung to defend against environmental insults. Pediatr. Pulmonol. 2011; 46:903\u2013912. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.21455","type":"journal-article","created":{"date-parts":[[2011,4,25]],"date-time":"2011-04-25T15:48:36Z","timestamp":1303746516000},"page":"903-912","source":"Crossref","is-referenced-by-count":3,"title":["Infant formula alters surfactant protein A (SP\u2010A) and SP\u2010B expression in pulmonary epithelial cells"],"prefix":"10.1002","volume":"46","author":[{"given":"Maurice G.","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance L.","family":"Atkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley R.","family":"Bruce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir 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