{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:08:25Z","timestamp":1773281305981,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,4,25]],"date-time":"2011-04-25T00:00:00Z","timestamp":1303689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study was designed to study effects of lung lavage versus the classical bolus instillation with a peptide\u2010based synthetic surfactant (lucinactant) in a model of Meconium Aspiration Syndrome (MAS). Eighteen newborn lambs received meconium and were randomized to: the experimental meconium installation (eMAS) group\u2014lambs with eMAS kept on conventional mechanical ventilation (control); the SF\u2010Bolus group\u2014eMAS receiving a lucinactant bolus (30\u2009mg\/ml); or the D\u2010SF\u2010Lavage group\u2014eMAS treated with dilute lucinactant bronchoalveolar lavage (10\u2009mg\/ml). Systemic and pulmonary arterial pressures, blood gases, and pulmonary mechanics were recorded for 180\u2009min. In addition, the intrapulmonary distribution of the lucinactant was determined using dye\u2010labeled microspheres. Following meconium instillation, severe hypoxia, hypercapnia, acidosis, and pulmonary hypertension developed, and dynamic compliance decreased (50% from baseline). After lung lavage with dilute lucinactant, gas exchange significantly improved versus bolus instillation (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Further, only in the lavage group did pulmonary arterial pressure return to basal values and dynamic compliance significantly increased. Both lung lavage and bolus techniques for the administration of lucinactant resulted in a non\u2010uniform lung distribution. In conclusion, in newborn lambs with respiratory failure and pulmonary hypertension induced by meconium, lung lavage with dilute lucinactant seems to be an effective and safe alternative for treatment for MAS. Pediatr. Pulmonol. 2011; 46:991\u2013999. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.21460","type":"journal-article","created":{"date-parts":[[2011,4,25]],"date-time":"2011-04-25T19:59:30Z","timestamp":1303761570000},"page":"991-999","source":"Crossref","is-referenced-by-count":16,"title":["Bronchoalveolar lavage versus bolus administration of lucinactant, a synthetic surfactant in meconium aspiration in newborn 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