{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T10:40:59Z","timestamp":1787913659170,"version":"build-2784847793"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,4,25]],"date-time":"2011-04-25T00:00:00Z","timestamp":1303689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"none reported"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Non\u2010invasive ventilation (NIV) has been shown to be effective in different causes of respiratory failure in both adult and pediatric patients. However, its role in status asthmaticus (SA) remains unclear. We designed a prospective study to assess the feasibility of NIV in children with SA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Prospective observational study, over a 4.5\u2010year period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patient selection<\/jats:title>\n                    <jats:p>Children with SA unresponsive to conventional therapy with a modified Wood's clinical asthma score (m\u2010WCAS) \u22654 and marked increased work of breathing, were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>Patients were placed on pressure support NIV. During NIV therapy, salbutamol was nebulized continuously and ipratropium bromide every 2\u2009hr; methyl\u2010prednisolone was given at a dose of 1\u20132\u2009mg\/kg\/6\u2009hr. Clinical variables were measured at baseline and at 1, 6, 12, 24, and 48\u2009hr.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the study period, there were 122 PICU admissions due to SA; 72 episodes fulfilled inclusion criteria. Baseline mean values were as follows: m\u2010WCAS of 5.7 points, heart rate (HR) of 166.7\u2009beats\/min, respiratory rate (RR) of 49.5\u2009breaths\/min and FiO\n                      <jats:sub>2<\/jats:sub>\n                      of 45.3%. In the first hour m\u2010WCAS fell 2.3\u2009\u00b1\u20091.5 points, HR 13.5\u2009\u00b1\u200914\u2009beats\/min, and RR 9.8\u2009\u00b1\u200910\u2009breaths\/min (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). After institution of NIV therapy, 5 children required intubation due to increasing respiratory distress. There was one case of massive subcutaneous emphysema, with no other serious adverse effects associated with NIV.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results show that NIV is a feasible therapy in children with SA unresponsive to conventional treatment. Pediatr. Pulmonol. 2011; 46:949\u2013955. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.21466","type":"journal-article","created":{"date-parts":[[2011,4,25]],"date-time":"2011-04-25T16:04:44Z","timestamp":1303747484000},"page":"949-955","source":"Crossref","is-referenced-by-count":69,"title":["Non\u2010invasive ventilation in pediatric status asthmaticus: A prospective observational 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