{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T16:25:25Z","timestamp":1771604725300,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"none reported."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Many children with idiopathic pulmonary arterial hypertension (IPAH) experience disease progression despite advanced medical therapy. In these children, heart\u2010lung or bilateral lung transplantation (BLTx) remain the only therapeutic options when other treatments fail. Data on functional outcome after BLTx in children with IPAH are limited. We report a multi\u2010center experience of BLTx for pediatric IPAH.<\/jats:p><jats:p>We performed a retrospective study including 25 centers within the International Pediatric Lung Transplant Collaborative. Children with IPAH who underwent BLTx were included (1996\u20132006).<\/jats:p><jats:p>Twenty\u2010three children underwent BLTx for IPAH, most of whom were in WHO class III or IV level of function pre\u2010transplantation. At 6 months post\u2010transplantation, 82% of children reported improvement in level of function to WHO class I. The median FEV<jats:sub>1<\/jats:sub> was 89% (12\u2013126) of predicted at 12 months post\u2010transplantation. Ten patients (44%) developed BOS at a median of 42 months (3\u201385), of whom five died at a median of 27 months (4\u201386) post\u2010transplantation. Overall mortality was 4% at 3 months post\u2010transplantation. The median survival for children in this cohort was 45 months (2\u2013123).<\/jats:p><jats:p>Our data suggest that BLTx is a valuable therapeutic option for children with end\u2010stage IPAH with outcomes comparable to that after heart\u2010lung transplantation in children with pulmonary arterial hypertension or those patients undergoing lung transplantation for other indications. In the majority of children, a good cardiopulmonary function is possible following BLTx, making BLTx a good therapeutic option and maximizing donor organ utilization by allowing more hearts to be available for children needing cardiac transplantation. Pediatr. Pulmonol. 2011; 46:1121\u20131127. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ppul.21484","type":"journal-article","created":{"date-parts":[[2011,6,3]],"date-time":"2011-06-03T08:36:13Z","timestamp":1307090173000},"page":"1121-1127","source":"Crossref","is-referenced-by-count":29,"title":["Bilateral lung transplantation for pediatric idiopathic pulmonary arterial hypertension: A multi\u2010center experience"],"prefix":"10.1002","volume":"46","author":[{"given":"G.","family":"Schaellibaum","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.E.","family":"Lammers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Faro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Moreno\u2010Galdo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Parakininkas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.G.","family":"Schecter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Solomon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Boyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Conrad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Frischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Boehler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Benden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1183\/1025448x.00045019"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00064804"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200808-095GO"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.08.008"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2006.03.004"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000138104.83366.E9"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019501-200502000-00003"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20051"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.072314"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2006.096412"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.11.438"},{"key":"e_1_2_6_13_2","unstructured":"RichS editor.Executive summary from the World Symposium on Primary Pulmonary Hypertension 1998 Evian France September 6\u201310 1998 cosponsored by the World Health Organization. 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