{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:59:48Z","timestamp":1788872388470,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2011,6,16]],"date-time":"2011-06-16T00:00:00Z","timestamp":1308182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"none reported"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    There is paucity of data on the usefulness of Interferon (IFN)\u2010\u03b3 release assays in the diagnosis of latent tuberculosis infection (LTBI) in children. The aim of this study was to evaluate the concordance between tuberculin skin test (TST) and QuantiFERON\u00ae\u2010TB Gold in\u2010tube (QFT\u2010GIT) test, when used in contact screening to diagnose LTBI in asymptomatic children. We also aimed to determine if there is any correlation between age and the IFN\u2010\u03b3 response to the mitogen. Children assessed at Leicester Royal Infirmary and Glenfield hospital (Leicester, United Kingdom) as part of tuberculosis contact screening were studied. Two hundred and eighty three children (mean [SD] age 5.3 [4.1] years, 148 males) underwent clinical examination, chest radiograph, TST, and QFT\u2010GIT test. In this group, there was good agreement (\u03ba\u2009=\u20090.70 [95%CI\u2009=\u20090.57\u20130.83],\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.0001) between TST and QFT\u2010GIT. Of the 18 children in this group with an indeterminate QFT\u2010GIT test result, all except one were &lt;5\u2010years\u2010old. To study the correlation between age and the IFN\u2010\u03b3 response to the mitogen, results of 282 children who had QFT\u2010GIT test as part of tuberculosis contact screening during the study period were analyzed. A significant correlation was observed between age and the IFN\u2010\u03b3 response to the mitogen (r\u2009=\u20090.47,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001). Whilst our study re\u2010emphasizes the good overall concordance between TST and QFT\u2010GIT, the high rate of indeterminate results and the low IFN\u2010\u03b3 response to the mitogen seen in young children raise some concerns about the performance of IGRAs in this group. Pediatr Pulmonol. 2011; 46: 1225\u20131232. \u00a9 2011 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ppul.21494","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T18:53:13Z","timestamp":1308336793000},"page":"1225-1232","source":"Crossref","is-referenced-by-count":22,"title":["Concordance between tuberculin skin test and interferon\u2010\u03b3 assay and interferon\u2010\u03b3 response to mitogen in pediatric tuberculosis contacts"],"prefix":"10.1002","volume":"46","author":[{"given":"B.","family":"Thomas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Pugalenthi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Woltmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bankart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Hoskyns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,6,16]]},"reference":[{"key":"e_1_2_7_2_2","unstructured":"WHO Report 2010. Global tuberculosis control.http:\/\/whqlibdoc.who.int\/publications\/2010\/9789241564069_eng.pdfDate last accessed: February 20 2011."},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.048033"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(04)01206-X"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-149-3-200808050-00241"},{"key":"e_1_2_7_6_2","unstructured":"CG 117: tuberculosis: clinical diagnosis and management of tuberculosis and measures for its prevention and control.http:\/\/www.nice.org.uk\/nicemedia\/live\/13422\/53642\/53642.pdfDate last accessed: April 2 2011."},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00115110"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-1725"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.127555"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.143396"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-3618"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31819abf6b"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002624"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181a16394"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1722"},{"key":"e_1_2_7_16_2","unstructured":"QuantiFERON\u00ae\u2010TB Gold (In\u2010Tube Method) package insert. Cellestis Limited Carnegie Victoria Australia.http:\/\/www.cellestis.com\/IRM\/Company\/ShowPage.aspx? CPID = 1170. 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