{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:45:28Z","timestamp":1770965128316,"version":"3.50.1"},"reference-count":94,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"none reported."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Snoring is the most characteristic symptom of obstructive sleep\u2010disordered breathing (SDB) and recurrent wheezing is the most common clinical manifestation of asthma. The purpose of the present review is to outline the impact of SDB and recurrent wheezing\/asthma on sleep quality and to summarize the epidemiologic and pathophysiologic evidence supporting an association between the two disorders. Enlarged tonsils and adenoid or obesity predispose to obstructive sleep apneas and hypopneas which are accompanied by arousals, restless sleep, and frequently daytime sleepiness, inattention, hyperactivity, and academic difficulties. Subjects with history of wheezing are also at risk for sleep disturbance and daytime cognitive dysfunction.<\/jats:p><jats:p>Asthmatic children have more frequent snoring, apneas, and hypopneas during sleep than non\u2010asthmatic subjects and tonsillar hypertrophy mediates at least in part this epidemiologic association. In addition, preliminary evidence indicates that treatment of sleep apnea with adenotonsillectomy results in improved control of coexisting asthma. Elevated concentrations of leukotrienes and oxidative stress markers have been detected in the exhaled breath condensate of children with asthma and probably contribute to bronchoconstriction. Moreover, sleep apneic children have increased expression of leukotrienes and leukotriene receptors in adenotonsillar tissue. Viral respiratory infections may induce inflammation and oxidative stress in the asthmatic airway enhancing not only bronchospasm, but also biosynthesis of leukotrienes within pharyngeal lymphoid tissues, which promote adenotonsillar enlargement and sleep apnea.<\/jats:p><jats:p>In conclusion, taking under consideration the epidemiologic association between obstructive SDB and asthma, when one of the two disorders is diagnosed, the possibility of the other disease being present should be entertained. Pediatr. Pulmonol. 2011; 46:1047\u20131054. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ppul.21497","type":"journal-article","created":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T21:10:35Z","timestamp":1312233035000},"page":"1047-1054","source":"Crossref","is-referenced-by-count":53,"title":["Interactions of obstructive sleep\u2010disordered breathing with recurrent wheezing or asthma and their effects on sleep quality"],"prefix":"10.1002","volume":"46","author":[{"given":"Georgia","family":"Malakasioti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Gourgoulianis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Chrousos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasios","family":"Kaditis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,8]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.4.e69"},{"key":"e_1_2_10_3_2","unstructured":"National Heart Lung and Blood Institute. National Asthma Education and Prevention Program. Expert Panel Report: guidelines for the diagnosis and management of asthma 2007. Bethesda MD; 2007."},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.5.3358"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.06.738"},{"key":"e_1_2_10_6_2","doi-asserted-by":"crossref","first-page":"539","DOI":"10.3109\/02770900903580868","article-title":"Uncontrolled asthma among children: impairment in social functioning and sleep","volume":"47","author":"Dean BB","journal-title":"J Asthma"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20981"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2008.03.002"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200707-111MG"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.2.8564147"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.4.9702042"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000147565.74947.14"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200304-590OC"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200301-092OC"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200403-262OC"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.6.7952634"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcp.0000183059.52924.39"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2869.2002.00289.x"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2005.11.003"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2005.10.002"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000075218"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-008-0242-2"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2008.0080"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.112270"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.01.043"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00114209"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201001-0108OC"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(99)00109-7"},{"key":"e_1_2_10_29_2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1542\/peds.109.SE1.357","article-title":"Defining asthma in the preschool\u2010aged child","volume":"109","author":"Strunk RC","year":"2002","journal-title":"Pediatrics"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200504-525OC"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501193320301"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.2.345"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.4.e69"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1526-0542(02)00189-6"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2007.07.025"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.127433"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.78.5.413"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/21.4.379"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.154.9.923"},{"key":"e_1_2_10_40_2","first-page":"135","article-title":"Nocturnal symptoms and sleep disturbances in clinically stable asthmatic children","volume":"24","author":"Chugh IM","year":"2006","journal-title":"Asian Pac J Allergy Immunol"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70050-8"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2004.00432.x"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.299.6714.1491"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950130412"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.5.9809079"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.2.587"},{"key":"e_1_2_10_47_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.1.19"},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2004.00428.x"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20075"},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20606"},{"key":"e_1_2_10_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20599"},{"key":"e_1_2_10_52_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00088407"},{"key":"e_1_2_10_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21174"},{"key":"e_1_2_10_54_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200403-398OC"},{"key":"e_1_2_10_55_2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.5664\/jcsm.27397","article-title":"Obstructive sleep apnea syndrome and asthma: what are the links","volume":"5","author":"Alkhalil M","year":"2009","journal-title":"J Clin Sleep Med"},{"key":"e_1_2_10_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.10.046"},{"key":"e_1_2_10_57_2","first-page":"237","article-title":"Leukotriene B4 and 8\u2010isoprostane in exhaled breath condensate of children with episodic and persistent asthma","volume":"20","author":"Caballero Balanza S","year":"2010","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_10_58_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01766.x"},{"key":"e_1_2_10_59_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.6.1718"},{"key":"e_1_2_10_60_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.1.143"},{"key":"e_1_2_10_61_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2008.00927.x"},{"key":"e_1_2_10_62_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02733.x"},{"key":"e_1_2_10_63_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/138.5.1134"},{"key":"e_1_2_10_64_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.23"},{"key":"e_1_2_10_65_2","doi-asserted-by":"publisher","DOI":"10.1053\/smrv.2002.0261"},{"key":"e_1_2_10_66_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/145.2_Pt_1.317"},{"key":"e_1_2_10_67_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.6.7767513"},{"key":"e_1_2_10_68_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.060657"},{"key":"e_1_2_10_69_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.8.3521"},{"key":"e_1_2_10_70_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.01000.x"},{"key":"e_1_2_10_71_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.89.5.709"},{"key":"e_1_2_10_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(90)90015-B"},{"key":"e_1_2_10_73_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2005-0124OC"},{"key":"e_1_2_10_74_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-2746"},{"key":"e_1_2_10_75_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200408-1064OC"},{"key":"e_1_2_10_76_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2102"},{"key":"e_1_2_10_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)10321-5"},{"key":"e_1_2_10_78_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200412-1693OC"},{"key":"e_1_2_10_79_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1999.277.4.L831"},{"key":"e_1_2_10_80_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20285"},{"key":"e_1_2_10_81_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1986.03380130091034"},{"key":"e_1_2_10_82_2","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e31814257ed"},{"key":"e_1_2_10_83_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.4.942"},{"key":"e_1_2_10_84_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.111.1.170"},{"key":"e_1_2_10_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61554-2"},{"key":"e_1_2_10_86_2","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2010.489388"},{"key":"e_1_2_10_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2004.10.011"},{"key":"e_1_2_10_88_2","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1183\/09031936.93.01100902","article-title":"Nocturnal asthma: snoring, small pharynx and nasal CPAP","volume":"1","author":"Guilleminault C","year":"1988","journal-title":"Eur Respir J"},{"key":"e_1_2_10_89_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/137.6.1502"},{"key":"e_1_2_10_90_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00059706"},{"key":"e_1_2_10_91_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.100.4.1024"},{"key":"e_1_2_10_92_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21688"},{"key":"e_1_2_10_93_2","first-page":"212","article-title":"Does adenotonsillectomy affect the course of bronchial asthma and nasal allergy","volume":"523","author":"Saito H","year":"1996","journal-title":"Acta Otolaryngol Suppl"},{"key":"e_1_2_10_94_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21451"},{"key":"e_1_2_10_95_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200912-1930OC"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.21497","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.21497","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.21497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:47:59Z","timestamp":1697590079000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.21497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":94,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1002\/ppul.21497"],"URL":"https:\/\/doi.org\/10.1002\/ppul.21497","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}