{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T06:51:20Z","timestamp":1763967080503},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,9,8]],"date-time":"2011-09-08T00:00:00Z","timestamp":1315440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>During severe exacerbations, asthmatic children vary significantly in their response to high\u2010dose continuous \u03b2<jats:sub>2<\/jats:sub>\u2010adrenergic receptor (ADR\u03b2<jats:sub>2<\/jats:sub>) agonist therapy. Genetic polymorphisms have been identified within the ADR\u03b2<jats:sub>2<\/jats:sub> that may be functionally relevant, but few studies have been performed in this population. Our hypothesis was that genotypic differences are associated with magnitude of response to ADR\u03b2<jats:sub>2<\/jats:sub> agonist treatment during severe asthma exacerbations in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children aged 2\u201318 years admitted to the ICU (intensive care unit) with a severe asthma exacerbation between 2006 and 2008 were eligible. Genotyping of the ADR\u03b2<jats:sub>2<\/jats:sub> was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010nine children consented and were enrolled. Despite similar clinical asthma scores on admission, children with the Gly<jats:sup>16<\/jats:sup>Gly genotype at amino acid position 16 had significantly shorter ICU length of stay (LOS) and hospital LOS, compared to children with Arg<jats:sup>16<\/jats:sup>Arg and Arg<jats:sup>16<\/jats:sup>Gly genotypes. Children with either the Gln<jats:sup>27<\/jats:sup>Glu or Glu<jats:sup>27<\/jats:sup>Glu genotype at amino acid position 27 also had significantly shorter ICU LOS and hospital LOS compared to children with the Gln<jats:sup>27<\/jats:sup>Gln genotype. The Arg<jats:sup>16<\/jats:sup>Gly\u2010Gln<jats:sup>27<\/jats:sup>Gln haplotype was associated with the longest ICU LOS, but this was not statistically different from other haplotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this cohort of children with severe asthma exacerbations, ADR\u03b2<jats:sub>2<\/jats:sub> polymorphisms were associated with responses to therapy. Knowledge of the genetic profile of children with asthma may allow for targeted therapy during acute exacerbations. Pediatr Pulmonol. 2012; 47:233\u2013239. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.21544","type":"journal-article","created":{"date-parts":[[2011,9,8]],"date-time":"2011-09-08T18:47:02Z","timestamp":1315507622000},"page":"233-239","source":"Crossref","is-referenced-by-count":19,"title":["Beta\u2010adrenergic receptor polymorphisms associated with length of ICU stay in pediatric status asthmaticus"],"prefix":"10.1002","volume":"47","author":[{"given":"Christopher L.","family":"Carroll","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen A.","family":"Sala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron R.","family":"Zucker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig M.","family":"Schramm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,8]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.1.9907092"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.9.762"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17273-5"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200509-1519OC"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb\/8.3.334"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61906-0"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/02770900903199961"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61492-6"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.7.2109096"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00198a006"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/02770900801971792"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2041"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20394"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60987-8"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.19.10483"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2088"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.12.1119"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.064006"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.059386"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000243749.14555.E8"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.1.45"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.21544","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.21544","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T16:54:16Z","timestamp":1700585656000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.21544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,8]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1002\/ppul.21544"],"URL":"https:\/\/doi.org\/10.1002\/ppul.21544","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,8]]}}}