{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:13:44Z","timestamp":1772118824614,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,10,17]],"date-time":"2011-10-17T00:00:00Z","timestamp":1318809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There are limited data assessing bronchodilator responsiveness (BDR) in infants and toddlers with recurrent wheezing, and factors associated with a positive response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>In a multicenter study of children \u2264\u200936 months old, we assessed the prevalence of and factors associated with BDR among infants\/toddlers with recurrent episodes of wheezing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forced expiratory flows and volumes using the raised\u2010volume rapid thoracic compression method were measured in 76 infants\/toddlers [mean (SD) age 16.8 (7.6) months] with recurrent wheezing before and after administration of albuterol. Prior history of hospitalization or emergency department treatment for wheezing, use of inhaled or systemic corticosteroids, physician treatment of eczema, environmental tobacco smoke exposure, and family history of asthma or allergic rhinitis were ascertained.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Using the published upper limit of normal for post bronchodilator change (FEV\n                      <jats:sub>0.5<\/jats:sub>\n                      \u2009\u2265\u200913% and\/or FEF\n                      <jats:sub>25\u201375<\/jats:sub>\n                      \u2009\u2265\u200924%) in healthy infants, 24% (n\u2009=\u200918) of children in our study exhibited BDR. The BDR response was not associated with any clinical factor other than body size. Dichotomizing subjects into responders (defined by published limits of normal) or by quartile to identify children with the greatest change from baseline (4th quartile vs. other) did not identify any other factor associated with BDR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Approximately one quarter of infants\/toddlers with recurrent wheezing exhibited BDR at their clinical baseline. However, BDR in wheezy infants\/toddlers was not associated with established clinical asthma risk factors. Pediatr Pulmonol. 2012; 47:421\u2013428. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.21567","type":"journal-article","created":{"date-parts":[[2011,10,17]],"date-time":"2011-10-17T11:13:17Z","timestamp":1318849997000},"page":"421-428","source":"Crossref","is-referenced-by-count":14,"title":["Bronchodilator responsiveness in wheezy infants and toddlers is not associated with asthma risk factors"],"prefix":"10.1002","volume":"47","author":[{"given":"Jason","family":"Debley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanja","family":"Stanojevic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy G.","family":"Filbrun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Padmaja","family":"Subbarao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,17]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1542\/peds.109.SE1.362","article-title":"Development of wheezing disorders and asthma in preschool children","volume":"109","author":"Martinez FD","year":"2002","journal-title":"Pediatrics"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)63293-0"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200304-499OC"},{"key":"e_1_2_6_5_2","unstructured":"NIH\/NHLBI. National Asthma Education and Prevention Program Expert Panel Report 2: Guidelines for the Diagnosis and Management of Asthma."},{"key":"e_1_2_6_6_2","unstructured":"Global Strategy for Asthma Management and Prevention Global Initiative for Asthma (GINA) 2010. Available from:http:\/\/www.ginasthma.org\/Guidelines\/guidelines\u2010resources.html"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2003.12.019"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.80.6.2019"},{"key":"e_1_2_6_9_2","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1183\/09031936.94.07111995","article-title":"Improved detection of abnormal respiratory function using forced expiration from raised lung volume in infants with cystic fibrosis","volume":"7","author":"Turner DJ","year":"1994","journal-title":"Eur Respir J"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.5.7735598"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.3.9812063"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199807)26:1<35::AID-PPUL7>3.0.CO;2-H"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.2.9903026"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.3.2005080"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20387"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200408-1141ST"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1017\/PHN20062005"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.2.530"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.05.004"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.11.029"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.09.004"},{"key":"e_1_2_6_22_2","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1183\/09031936.93.06060868","article-title":"Airways hyperresponsiveness, bronchodilator response, allergy and smoking predict improvement in FEV1 during long\u2010term inhaled corticosteroid treatment. Dutch CNSLD Study Group","volume":"6","author":"Kerstjens HA","year":"1993","journal-title":"Eur Respir J"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.10.035"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1185\/03007990903485148"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.4.9912111"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.4.316"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200410-1404OC"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.06.005"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.03.023"},{"key":"e_1_2_6_30_2","first-page":"A1033","article-title":"Exhaled nitric oxide predicts persistence of wheezing, exacerbations, and decline in lung function in wheezy infants and toddlers","volume":"183","author":"Debley JSS","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501193320301"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.06.028"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.1.2005013"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116961"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.6.2004178"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200206-616OC"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200510-1552OC"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.21567","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.21567","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T12:54:50Z","timestamp":1696856090000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.21567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,17]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1002\/ppul.21567"],"URL":"https:\/\/doi.org\/10.1002\/ppul.21567","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.714297951.789952855","asserted-by":"object"}]},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,17]]}}}