{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T05:44:48Z","timestamp":1744177488010},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,2,10]],"date-time":"2012-02-10T00:00:00Z","timestamp":1328832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess within a feasibility study the correlation, agreement, and trending of continuous integrated distal capnography (dCap) with PaCO<jats:sub>2<\/jats:sub> in infants on HFV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Sixteen premature infants [median (range) gestational age: 26.5 (24.7\u201334.7) weeks], ventilated with HFV (mean\u2009\u00b1\u2009SD airway pressure: 8.1\u2009\u00b1\u20092.1\u2009cmH<jats:sub>2<\/jats:sub>O, FiO<jats:sub>2<\/jats:sub>: 0.39\u2009\u00b1\u20090.21) for RDS, intubated with a double\u2010lumen endotracheal\u2010tube and whose data were recorded on a bedside computer participated in the study. Side\u2010stream dCap was measured via the extra\u2010port of a double\u2010lumen endotracheal\u2010tube by a Microstream capnograph, with a specially designed software for HFV and compared with simultaneous PaCO<jats:sub>2<\/jats:sub>. Integrated time\u2010window analysis of the data was performed retrospectively on data collected prospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Analysis included 195 measurements. The correlation of dCap with PaCO<jats:sub>2<\/jats:sub> (r\u2009=\u20090.68, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001) and the agreement (bias\u2009\u00b1\u2009precision: \u22122.0\u2009\u00b1\u200910.7\u2009mmHg) were adequate. Area under the ROC curves for dCap to detect high (&gt;60\u2009mmHg) or low (&lt;35\u2009mmHg) PaCO<jats:sub>2<\/jats:sub> was 0.79 (CI: 0.70\u20130.89) and 0.87 (CI: 0.73\u20131.00), respectively; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001. Changes in dCap and in PaCO<jats:sub>2<\/jats:sub> for consecutive measurements within each patient were adequately correlated (r\u2009=\u20090.65, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Continuous integrated dCap is feasible in premature infants ventilated with HFV and can be helpful for trends and alarm for unsafe levels of PaCO<jats:sub>2<\/jats:sub>. Pediatr Pulmonol. 2012. 47:876\u2013883. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.22524","type":"journal-article","created":{"date-parts":[[2012,2,10]],"date-time":"2012-02-10T16:13:18Z","timestamp":1328890398000},"page":"876-883","source":"Crossref","is-referenced-by-count":6,"title":["Continuous integrated distal capnography in infants ventilated with high frequency ventilation"],"prefix":"10.1002","volume":"47","author":[{"given":"Amir","family":"Kugelman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arieh","family":"Riskin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irit","family":"Shoris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Ronen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris Shalev","family":"Stein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Bader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,10]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000104.pub2"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1542\/peds.98.6.1035","article-title":"High frequency jet ventilation in the early management of respiratory distress syndrome is associated with a greater risk for adverse outcomes","volume":"98","author":"Wiswell TE","year":"1996","journal-title":"Pediatrics"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1542\/peds.98.5.918","article-title":"Effects of hypocarbia on the development of cystic periventricular leukomalacia in premature infants treated with high\u2010frequency jet ventilation","volume":"98","author":"Wiswell TE","year":"1996","journal-title":"Pediatrics"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199106010-00007"},{"key":"e_1_2_6_6_2","first-page":"1125","article-title":"Perinatal factors and periventricular\u2013intraventricular hemorrhage in preterm infants","volume":"140","author":"Van de Bor M","year":"1986","journal-title":"Am J Dis Child"},{"key":"e_1_2_6_7_2","first-page":"904","article-title":"Transfusion therapy in neonates","volume":"145","author":"Strauss RG","year":"1991","journal-title":"Am J Dis Child"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.4_Spec_No.345"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.3.795"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1984.56.3.553"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7210672"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.064717"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1300"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950120305"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.101.4.648"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/10543400701329422"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.2003.00170.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199707000-00028"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-198710000-00006"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198807000-00020"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03005583"},{"key":"e_1_2_6_22_2","unstructured":"KugelmanA RiskinA ShorisI BaderD.Capnography in premature infants ventilated with high frequency ventilation: a pilot study. 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