{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:08:33Z","timestamp":1790867313811,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T00:00:00Z","timestamp":1332115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Clinical Research Department of Montpellier University Hospital Centre","award":["AOI 2005"],"award-info":[{"award-number":["AOI 2005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the effects of nasal continuous positive airway pressure (nCPAP) and conventional oxygen therapy on the clinical signs of respiratory distress and the respiratory muscle workload in acute viral bronchiolitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective, randomized, monocentric study carried out in the pediatric intensive care unit (PICU) of a university hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Infants &lt;6 months old, admitted to the PICU with severe respiratory syncytial virus bronchiolitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Intervention<\/jats:title><jats:p>The patients were randomized into two groups for 6\u2009hr. The nCPAP group (n\u2009=\u200910) received 6\u2009cmH<jats:sub>2<\/jats:sub>O pressure support delivered by a jet flow generator and the control group (n\u2009=\u20099) received an air\/oxygen mixture from a heated humidifier. Respiratory distress was assessed by the modified Wood's clinical asthma score (m\u2010WCAS), and inspiratory muscle work was evaluated by calculating the pressure\u2013time product per breath (PTP<jats:sub>insp<\/jats:sub>\/breath) and per minute (PTP<jats:sub>insp<\/jats:sub>\/min) from the esophageal pressure (Pes) recordings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Main Results<\/jats:title><jats:p>Compared with control condition, nCPAP decreased m\u2010WCAS [\u22122.4 (1.05) vs. \u22120.5 (1.3), <jats:italic>P<\/jats:italic>\u2009=\u20090.03], PTPes<jats:sub>insp<\/jats:sub>\/breath [\u22129.7 (5.7) vs. \u22121.4 (8.2), <jats:italic>P<\/jats:italic>\u2009=\u20090.04], PTPes<jats:sub>insp<\/jats:sub>\/min [\u2212666 (402) vs. \u2212116 (352), <jats:italic>P<\/jats:italic>\u2009=\u20090.015], and FiO<jats:sub>2<\/jats:sub> [\u22127 (10) vs. +5 (15), <jats:italic>P<\/jats:italic>\u2009=\u20090.05]. Significant worsening of m\u2010WCAS was only observed in the control group (4\/9 vs. 0\/10, <jats:italic>P<\/jats:italic>\u2009=\u20090.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>nCPAP rapidly decreased inspiratory work in young infants with acute bronchiolitis. Improvement in the respiratory distress score at 6\u2009hr was proportional to the initial clinical severity, suggesting the importance of rapid nCPAP initiation in the more severe forms of the disease. Pediatr Pulmonol. 2013; 48:45\u201351. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.22533","type":"journal-article","created":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T21:09:28Z","timestamp":1332191368000},"page":"45-51","source":"Crossref","is-referenced-by-count":85,"title":["6\u2009cmH<sub>2<\/sub>O continuous positive airway pressure versus conventional oxygen therapy in severe viral bronchiolitis: A randomized 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