{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:13:52Z","timestamp":1772118832319,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T00:00:00Z","timestamp":1332115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Adherence to current guidelines for treatment of non\u2010complicated community\u2010acquired pneumonia (CAP) in children, recommending penicillin or ampicillin as first\u2010line treatment, has been poor. Our objective was to examine whether cefuroxime confers an advantage over penicillin or ampicillin for the treatment of children hospitalized with non\u2010complicated CAP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>All children aged 3 months to 2 years with non\u2010complicated CAP treated with penicillin or ampicillin or cefuroxime, admitted during 2003\u20132008, in the Departments of Pediatrics, Hadassah University Medical Center were included. Presenting signs, symptoms, laboratory findings at presentation, clinical parameters including number of days with IV antibiotics, oxygen treatment, length of hospital stay, change of antibiotics, and clinical course 72\u2009hr and 1 week after admission, were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 319 children admitted for non\u2010complicated CAP, 66 were treated with IV penicillin or ampicillin, 253 with IV cefuroxime. Number of days of IV treatment, days of oxygen requirement, and days of hospitalization were similar (2.36\u2009\u00b1\u20091.6 days vs. 2.59\u2009\u00b1\u20091.6 days, 0.31\u2009\u00b1\u20091.2 days vs. 0.64\u2009\u00b1\u20091.3 days, and 2.67\u2009\u00b1\u20091.4 days vs. 2.96\u2009\u00b1\u20091.7 days, respectively). Treatment failure was not significantly different (7.6% vs. 4.7%). The number of patients who were febrile or required oxygen 72\u2009hr after admission was similar (13.0% vs. 16.5% and 8.7% vs. 20.9%, respectively). One week after admission no difference between the two groups was seen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In previously healthy children, parenteral penicillin or ampicillin for treatment of non\u2010complicated CAP in\u2010hospital is as effective as cefuroxime, and should remain the recommended first\u2010line therapy. Pediatr Pulmonol. 2013; 48:52\u201358. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.22534","type":"journal-article","created":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T17:10:22Z","timestamp":1332177022000},"page":"52-58","source":"Crossref","is-referenced-by-count":13,"title":["Antibiotic treatment of children with community\u2010acquired pneumonia: Comparison of penicillin or ampicillin versus cefuroxime"],"prefix":"10.1002","volume":"48","author":[{"given":"Yael","family":"Dinur\u2010Schejter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malena","family":"Cohen\u2010Cymberknoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariel","family":"Tenenbaum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Averbuch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigmund","family":"Kharasch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eitan","family":"Kerem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,3,19]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2006.03.011"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2007.06.037"},{"key":"e_1_2_5_4_2","first-page":"1","article-title":"Antibiotics for community acquired pneumonia in children","volume":"3","author":"Kabra SK","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_5_2","first-page":"977","article-title":"Diagnosis and Management of Community\u2010Acquired Pneumonia in Childhood\u2014South African Thoracic Society Guidelines","volume":"95","author":"Zar HJ","year":"2005","journal-title":"S Afr Med J"},{"key":"e_1_2_5_6_2","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/01.mcp.0000159831.82529.85","article-title":"Community\u2010acquired pneumonia in children","volume":"11","author":"Sinaniotis CA","journal-title":"Curr Opin Pulm Med"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra011994"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e3180312cd5"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.11136\/adc.2006.111625"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/313959"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199707000-00007"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.90.2.223"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.102.6.1369"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-003-1397-2"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.1.1"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1086\/497594"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.4065\/81.12.1567"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20383"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.15.1458"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1086\/338066"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhin.2000.0770"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/41.suppl_3.5"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg254"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1086\/377534"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00008360"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1086\/381886"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.10.1399"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200104000-00005"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1086\/511159"},{"key":"e_1_2_5_30_2","unstructured":"British Thoracic Society.Guidelines for the management of community acquired pneumonia in adults 2004 update.http:\/\/wwwbrit\u2010thoracicorguk\/c2\/uploads\/MACAPrevisedApr04pdf 2004."},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2006.01387.x"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2006.056556"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(01)00170-0"},{"key":"e_1_2_5_34_2","volume-title":"The World Health Report 2005. 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