{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:16:08Z","timestamp":1760955368816},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,9,19]],"date-time":"2012-09-19T00:00:00Z","timestamp":1348012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Science Council (NSC) of the Taiwan","award":["99-2314-B-002-025-MY3"],"award-info":[{"award-number":["99-2314-B-002-025-MY3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>CATCH 22 syndrome is a medical acronym for multiple abnormalities, especially cardiac defect. The patients with congenital heart disease (CHD) usually have more complicated post\u2010surgery course.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed 4\u2010year experience in our hospital to define the lower airway anomalies and the clinical implications in patients with CATCH 22 syndrome and CHD. From 2004 to 2007, 18 patients who underwent computed tomography for planning of cardiovascular treatment were enrolled. Detection of airway anomalies were performed on computed tomography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Characteristic dysmorphic facial features were noted in 8 out of 18 patients (44%). Ten patients (55.6%) had mild to moderate tracheal or bronchial stenosis. Five patients (28%) had tracheomalacia or bronchomalacia. Comparing to control group, patients received the first major surgery with a median hospital stays of 42 days in study group had a significantly longer hospital stay (42 vs. 16, <jats:italic>P<\/jats:italic>\u2009=\u20090.005) and longer duration of ventilator usage (16 vs. 4, <jats:italic>P<\/jats:italic>\u2009=\u20090.014). The difference of the mean position of the carina on computed tomography image between study groups and control groups was about three\u2010quarters of a vertebral body height (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Conclusions: Patients with CATCH 22 syndrome and CHD had a shorter length of trachea compared to that of the age\u2010matched similar CHD. The incidence of associated lower airway anomalies in CHD children with CATCH 22 syndrome was higher. It may lead to longer time of ventilator support after surgery as well as total hospital stays than those of CHD without CATCH 22 syndrome. Pediatr Pulmonol. 2013; 48:587\u2013591. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.22674","type":"journal-article","created":{"date-parts":[[2012,9,19]],"date-time":"2012-09-19T13:02:13Z","timestamp":1348059733000},"page":"587-591","source":"Crossref","is-referenced-by-count":15,"title":["Lower airway anomalies in children with CATCH 22 syndrome and congenital heart 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