{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:28:55Z","timestamp":1758475735069,"version":"3.37.3"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,11,9]],"date-time":"2012-11-09T00:00:00Z","timestamp":1352419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cystic fibrosis (CF) is characterized by recurrent respiratory infections and progressive lung disease. Although environmental factors account for 50% of the variation in CF lung function, few specific exposures have been identified. Studies using small study samples focusing on environmental allergies in CF have had inconsistent results. Our objective was to examine the role of environmental allergies in upper and lower respiratory tract morbidities in CF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1,321 subjects with CF were recruited through the U.S. CF Twin\u2013Sibling Study. Questionnaires were used to determine the presence\/absence of environmental allergies. Questionnaires, chart review, and U.S. CF Foundation Patient Registry data were used to track outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Within the study sample 14% reported environmental allergies. Environmental allergies were associated with a higher risk of sinus disease (adjusted OR: 2.68; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and nasal polyps (adjusted OR: 1.74; <jats:italic>P<\/jats:italic>\u2009=\u20090.003). Environmental allergies were also associated with a more rapid decline in lung function (additional \u22121.1%\/year; <jats:italic>P<\/jats:italic>\u2009=\u20090.001). However, allergies were associated with a later median age of acquisition of <jats:italic>Pseudomonas aeruginosa<\/jats:italic> (6.6 years vs. 4.4 years; log rank <jats:italic>P<\/jats:italic>\u2009=\u20090.027). The reported use of common allergy medications, anti\u2010histamines and leukotriene inhibitors, did not alter the frequency of respiratory morbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Environmental allergies are associated with an increased risk of sinus disease and nasal polyps and a more rapid decline in CF lung function, but may have a protective effect against the acquisition of <jats:italic>P. aeruginosa<\/jats:italic>. Prospective studies are needed to confirm these associations which have implications for more aggressive management of allergies. Pediatr Pulmonol. 2013; 48:857\u2013864. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.22700","type":"journal-article","created":{"date-parts":[[2012,11,9]],"date-time":"2012-11-09T16:58:39Z","timestamp":1352480319000},"page":"857-864","source":"Crossref","is-referenced-by-count":4,"title":["Environmental allergies and respiratory morbidities in cystic fibrosis"],"prefix":"10.1002","volume":"48","author":[{"given":"Joseph M.","family":"Collaco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher B.","family":"Morrow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deanna M.","family":"Green","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garry R.","family":"Cutting","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Peter J.","family":"Mogayzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,11,9]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.05.018"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.4.417"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.6.9912100"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.4.e333"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200306-779OC"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027784"},{"key":"e_1_2_6_8_2","first-page":"547","article-title":"Vital signs: asthma prevalence, disease characteristics, and self\u2010management education: United States, 2001\u20132009","volume":"60","author":"Anonymous","year":"2011","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_6_9_2","first-page":"1040","article-title":"The 2007 GOLD guidelines: a comprehensive care framework","volume":"54","author":"Gold PM","year":"2009","journal-title":"Respir Care"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200603-423OC"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2010.06.002"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.1996.tb00399.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.56.6.455"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.35.10.768"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(94)90238-0"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.57.8.582"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.53.11.873"},{"key":"e_1_2_6_18_2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/BF02914533","article-title":"The relationship between atopy and cystic fibrosis","volume":"9","author":"Wilmott RW","year":"1991","journal-title":"Clin Rev Allergy"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)91862-6"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.51.7.507"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199803)25:3<159::AID-PPUL5>3.0.CO;2-H"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21512"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20398"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200410-1335OC"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950150204"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.1.9712108"},{"key":"e_1_2_6_27_2","first-page":"141","article-title":"Allergy in cystic fibrosis","volume":"35","author":"Carswell F","year":"1979","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.50.6.477"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq392"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1961.03040050014004"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-11-140"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.1999.00813.x"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.12.989"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.suppl_2.S79"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2003.00677.x"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino10.225"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.75.6.498"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05879.x"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2004.01.014"},{"key":"e_1_2_6_40_2","first-page":"459","article-title":"Association of TGFB1 gene polymorphism \u2212509C\/T with disease severity in childhood allergic rhinitis","volume":"45","author":"Zhu XJ","year":"2010","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1990.tb02803.x"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.07.044"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.2009"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10127"},{"key":"e_1_2_6_45_2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jpeds.2007.03.006","article-title":"Risk factors for rate of decline in forced expiratory volume in one second in children and adolescents with cystic fibrosis","volume":"151","author":"Konstan MW","year":"2007","journal-title":"J Pediatr"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.22700","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.22700","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.22700","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T03:54:07Z","timestamp":1700625247000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.22700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,9]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1002\/ppul.22700"],"URL":"https:\/\/doi.org\/10.1002\/ppul.22700","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"type":"print","value":"8755-6863"},{"type":"electronic","value":"1099-0496"}],"subject":[],"published":{"date-parts":[[2012,11,9]]}}}