{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:39:28Z","timestamp":1789533568920,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,12,31]],"date-time":"2012-12-31T00:00:00Z","timestamp":1356912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"none reported"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Juvenile dermatomyositis (JDM) is the main cause of chronic idiopathic inflammatory myopathy of autoimmune origin in children. The aim of this multicenter prospective study was to describe respiratory status and treatment of children followed for JDM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and patients<\/jats:title><jats:p>Clinical manifestations, pulmonary function tests (PFT), chest high\u2010resolution computed tomography (HRCT) scan results, and treatments and their adverse effects were analyzed in children followed for JDM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010one patients (median age: 9.9 years; range: 20 months\u201318 years) were included. The median of disease duration at the time of the analysis was 3 years (range: 6 months\u20139 years 4 months). Overall 16 (76%) of 21 children presented with a respiratory involvement related to JDM including interstitial lung disease (n\u2009=\u20093) and\/or respiratory muscle involvement (n\u2009=\u20097). Seven patients presented with other nonspecific manifestations. Three children had aspiration pneumonia. A chest HRCT was performed in 15 children, and abnormalities were observed in 12. PFT were performed in 20 of 21 patients. Seven showed functional abnormalities: restrictive ventilatory defect (n\u2009=\u20093) or obstructive ventilatory defect (n\u2009=\u20094). Six patients had abnormal respiratory muscle tests, including three with a restrictive ventilatory defect and one with an obstructive ventilatory defect. One other child with an acute aspiration pneumonia had a clearly muscle respiratory involvement but was too young to perform respiratory muscle tests and confirm this diagnosis. Treatment comprised systemic corticosteroid for all patients and adjuvant immunosuppressive therapy for 11. Adverse effects linked to treatment were reported in eight patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The frequency of lung involvement in children with JDM justifies systematic respiratory assessment with PFT including measures of respiratory muscle strength. We suggest that a chest HRCT scan is indicated in cases of respiratory symptoms and\/or PFT abnormalities. Longitudinal studies are needed to assess pediatric characteristics, long\u2010term outcomes, and responses to treatment taking into account the risk\u2013benefit ratio. <jats:bold>Pediatr Pulmonol. 2013; 48:1016\u20131025.<\/jats:bold> \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.22742","type":"journal-article","created":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T20:16:27Z","timestamp":1357071387000},"page":"1016-1025","source":"Crossref","is-referenced-by-count":33,"title":["The lung is involved in juvenile dermatomyositis"],"prefix":"10.1002","volume":"48","author":[{"given":"Guillaume","family":"Pouessel","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Pneumologie et Allergologie P\u00f4le de P\u00e9diatrie, Centre de Comp\u00e9tence des Maladies Respiratoires Rares de L'enfant, H\u00f4pital Jeanne de Flandre et Universit\u00e9 Lille 2 CHRU de Lille Lille France"},{"name":"Service de P\u00e9diatrie Pavillon M\u00e9dico\u2010Chirurgical de P\u00e9diatrie, H\u00f4pital Victor Provo 59056 Roubaix Cedex 1 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Deschildre","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Pneumologie et Allergologie P\u00f4le de P\u00e9diatrie, Centre de Comp\u00e9tence des Maladies Respiratoires Rares de L'enfant, H\u00f4pital Jeanne de Flandre et Universit\u00e9 Lille 2 CHRU de Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Le Bourgeois","sequence":"additional","affiliation":[{"name":"Service de Pneumologie et Allergologie P\u00e9diatriques Centre de R\u00e9f\u00e9rence Des Maladies Respiratoires Rares de L'enfant, H\u00f4pital Necker\u2010Enfants Malades, Universit\u00e9 Paris Descartes, Assistance Publique des H\u00f4pitaux de Paris Paris 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