{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T02:39:18Z","timestamp":1783564758338,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,8]],"date-time":"2013-02-08T00:00:00Z","timestamp":1360281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Respiratory syncytial virus (RSV) is one of the leading causes of acute lower respiratory infection (ALRI) in infants and young children. Although ALRI is a major public health problem in developing countries located in tropical areas, studies about RSV epidemiology in these regions are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a retrospective cohort study, we investigated the epidemiology and predictive variables that reflect disease severity and mortality in young children hospitalized with ALRI due to RSV in Colombia, South\u2010America, during a 2\u2010year period (2009\u20132011).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of a total of 6,344 children with a diagnosis of ALRI, we selected 2,147 (33.8%) that were positive for RSV. After controlling for pre\u2010existing conditions, we found that independent predictors of severe disease in our population included age &lt;6 months (RR 2.01; CI 95% 1.70\u20132.38; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), prematurity (RR 1.61; CI 95% 1.20\u20132.17; <jats:italic>P<\/jats:italic>\u2009=\u20090.001), congenital heart disease (RR 2.03; CI 95% 1.16\u20133.54; <jats:italic>P<\/jats:italic>\u2009=\u20090.013), and mixed RSV\u2010adenovirus infection (RR 2.09; CI 95% 1.60\u20132.73; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Multivariate analysis identified that cancer (RR 31.60; CI 95% 5.97\u2013167.13; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) is a predictor of mortality in our RSV\u2010infected pediatric population independently of age and other co\u2010morbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>RSV is an important cause of ALRI in infants and young children living in tropical regions, especially during the rainy season. The identified predictors of severe disease and mortality should be taken into account when planning interventions to reduce the burden of ALRI in young children living in these regions. <jats:bold>Pediatr Pulmonol. 2014; 49:269\u2013276.<\/jats:bold> \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.22781","type":"journal-article","created":{"date-parts":[[2013,2,8]],"date-time":"2013-02-08T15:37:05Z","timestamp":1360337825000},"page":"269-276","source":"Crossref","is-referenced-by-count":67,"title":["Predictors of severity and mortality in children hospitalized with respiratory syncytial virus infection in a tropical region"],"prefix":"10.1002","volume":"49","author":[{"given":"Diego Andr\u00e9s","family":"Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Fundaci\u00f3n Hospital La Misericordia Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos E.","family":"Rodr\u00edguez\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine Universidad Nacional de Colombia Bogot\u00e1 Colombia"},{"name":"Department of Pediatric Pulmonology and Pediatric Critical Care Medicine, School of Medicine Universidad El Bosque Bogota Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Constanza","family":"C\u00e1rdenas","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Hospital La Misericordia Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivonne Emilce","family":"Quilaguy","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Hospital La Misericordia Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leydy Yasmin","family":"Mayorga","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Hospital La Misericordia Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luz Marlesvy","family":"Falla","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology and Pediatric Critical Care Medicine, School of Medicine Universidad El Bosque Bogota Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Nino","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonary Medicine Penn State Hershey Children's Hospital, Pennsylvania State University College of Medicine Hershey Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762006000300014"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-007-0081-3"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60206-1"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/13.Supplement_6.S454"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197303082881005"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.1998.00213.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000053882.70365.c9"},{"key":"e_1_2_5_9_1","volume-title":"Air pollution management in two Colombian cities: case study. 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