{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T16:58:33Z","timestamp":1784912313162,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T00:00:00Z","timestamp":1371513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"none reported"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The present study aims to evaluate the efficacy and complications of combined noninvasive ventilation (NIV) and assisted coughing by mechanical in\u2010exsufflator (MIE) for acute respiratory failure (ARF) in children with neuromuscular disease (NMD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective study was conducted in the pediatric intensive care unit. Children with NMD and ARF treated by combined NIV and MIE were included. Treatment success was defined as freedom from tracheal intubation during the hospital stay. Physiologic indices including PaO<jats:sub>2<\/jats:sub>, PaCO<jats:sub>2<\/jats:sub>, pH, and PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> were recorded before and 12, 24\u2009hr after the use of NIV\/MIE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Combined NIV\/MIE was used in 15 NMD children (mean: 8.1 years, range: 3 months to 18 years) with 16 cases of ARF. There was no mortality in this cohort. Treatment success was achieved in 12 cases (75%), including six cases (38%) demanding \u201cDo Not Intubate.\u201d ARF was due to pneumonia, with a mean baseline PaCO<jats:sub>2<\/jats:sub> of 73.2\u2009\u00b1\u200919.0\u2009mmHg. In the success group, hypercarbia and acidosis improved after use of NIV\/MIE for 24\u2009hr (PaCO<jats:sub>2<\/jats:sub>: 71.7\u2009\u00b1\u200918.6\u2009mmHg vs. 55.8\u2009\u00b1\u200911.6\u2009mmHg, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01; pH: 7.29\u2009\u00b1\u20090.07 vs. 7.38\u2009\u00b1\u20090.05, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). All patients tolerated NIV\/MIE well despite transient skin pressure sores in five cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Combined NIV\/MIE is a safe and effective approach to rapidly improve physiologic indices and decrease the need for intubation in NMD children with ARF. NIV\/MIE provides a good alternative for those refusing intubation. <jats:bold>Pediatr Pulmonol. 2014; 49:589\u2013596.<\/jats:bold> \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.22827","type":"journal-article","created":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T05:46:35Z","timestamp":1371534395000},"page":"589-596","source":"Crossref","is-referenced-by-count":30,"title":["Combined noninvasive ventilation and mechanical in\u2010exsufflator in the treatment of pediatric acute neuromuscular respiratory failure"],"prefix":"10.1002","volume":"49","author":[{"given":"Tai\u2010Heng","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pediatrics Kaohsiung Medical University Hospital, Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Division of Pediatric Emergency, Department of Emergency Kaohsiung Medical University Hospital, Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong\u2010Hau","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kaohsiung Medical University Hospital, Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Pediatrics, Faculty of Medicine, College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Graduate Institute of Medicine, College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiunn\u2010Ren","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kaohsiung Medical University Hospital, Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Pediatrics, Faculty of Medicine, College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zen\u2010Kong","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kaohsiung Medical University Hospital, Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Pediatrics, Faculty of Medicine, College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u2010Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kaohsiung Medical University Hospital, Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Chen","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kaohsiung Medical University Hospital, Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"San\u2010Nan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kaohsiung Medical University Hospital, Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Graduate Institute of Medicine, College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuh\u2010Jyh","family":"Jong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kaohsiung Medical University Hospital, Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Graduate Institute of Medicine, College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Laboratory Medicine Kaohsiung Medical University Hospital, Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Biological Science and Technology National Chiao Tung University Hsin\u2010Chu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2952C"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2002.019562"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.5.1390"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.4.1406"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.78.3.253"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(81)90413-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.105.1.237"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199202000-00008"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.2.278"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21617"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001340051171"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PHM.0000151941.97266.96"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000033797.79530.16"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073807305788"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70272-8"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073810381924"},{"key":"e_1_2_8_18_1","first-page":"1473","article-title":"The addition of mechanical insufflation\/exsufflation shortens airway\u2010clearance sessions in neuromuscular patients with chest infection","volume":"54","author":"Chatwin M","year":"2009","journal-title":"Respir Care"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00048102"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000251299.54608.13"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-981655"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3182388ad1"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2006.09.006"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073812436605"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.phm.0000184097.17189.93"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000225089.21176.0B"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-1615"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000092018.56823.02"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.207"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950170208"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2952H"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000090777"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.22827","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.22827","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.22827","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T13:19:23Z","timestamp":1696511963000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.22827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,18]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1002\/ppul.22827"],"URL":"https:\/\/doi.org\/10.1002\/ppul.22827","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,18]]}}}