{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:40:45Z","timestamp":1791582045266,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,12,23]],"date-time":"2013-12-23T00:00:00Z","timestamp":1387756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Incentive Fund of Research of HCPA (FIPE)","award":["not applicable"],"award-info":[{"award-number":["not applicable"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Post\u2010infectious bronchiolitis obliterans (PBO) is a chronic lung disease characterized by the persistence of continuous obstructive respiratory symptoms following an acute and severe respiratory infection in children under 3 years old. The purpose of the present study was to investigate if adolescents and adults with diagnosis of PBO have reduced aerobic capacity and identify factors related with exercise performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A convenience sample of 16 patients (10\u201323 years) that have consulted with established diagnosis of PBO in a tertiary care clinic were studied. Fourteen healthy matched subjects were selected from the community to serve as controls. They performed resting lung function tests and cycle incremental cardiopulmonary exercise tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Peak aerobic capacity (peak <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/ppul22929-math-0001.gif\" xlink:title=\"urn:x-wiley:87556863:media:ppul22929:ppul22929-math-0001\"\/>) was significantly lower in patients compared to controls (84\u2009\u00b1\u200915 vs. 101\u2009\u00b1\u200917% pred; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Peak <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/ppul22929-math-0002.gif\" xlink:title=\"urn:x-wiley:87556863:media:ppul22929:ppul22929-math-0002\"\/> was correlated with rest inspiratory capacity (IC) (r\u2009=\u20090.60; <jats:italic>P<\/jats:italic>\u2009=\u20090.02) and marginally with forced expiratory volume in the first second (FEV<jats:sub>1<\/jats:sub>) (r\u2009=\u20090.45; <jats:italic>P<\/jats:italic>\u2009=\u20090.09). Additionally, FEV<jats:sub>1<\/jats:sub> was correlated with IC (r\u2009=\u20090.83; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) and residual volume\/total lung capacity (r\u2009=\u2009\u22120.91, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adolescent and adult patients with PBO had reduced peak <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/ppul22929-math-0003.gif\" xlink:title=\"urn:x-wiley:87556863:media:ppul22929:ppul22929-math-0003\"\/> compared to healthy controls. Peak <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/ppul22929-math-0004.gif\" xlink:title=\"urn:x-wiley:87556863:media:ppul22929:ppul22929-math-0004\"\/> was correlated with parameters of airflow limitation and rest hyperinflation. The greater the air flow limitation (lower FEV<jats:sub>1<\/jats:sub>) the greater the hyperinflation, air trapping, and aerobic capacity reduction. <jats:bold>Pediatr Pulmonol. 2014; 49:911\u2013918.<\/jats:bold> \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.22929","type":"journal-article","created":{"date-parts":[[2013,12,23]],"date-time":"2013-12-23T11:47:02Z","timestamp":1387799222000},"page":"911-918","source":"Crossref","is-referenced-by-count":19,"title":["Exercise capacity in adolescent and adult patients with post infectious bronchiolitis obliterans"],"prefix":"10.1002","volume":"49","author":[{"given":"Luiz Felipe","family":"Frohlich","sequence":"first","affiliation":[{"name":"Postgraduate Studies Program in Pulmonology School of Medicine Federal University of Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo J.C.","family":"Vieira","sequence":"additional","affiliation":[{"name":"Cardiology School of Medicine Federal University of Rio Grande do Sul Porto Alegre Brazil"},{"name":"Exercise Pathophysiology Research Laboratory Hospital de Cl\u00ednicas de Porto Alegre Porto Alegre RS Brazil"},{"name":"Department of Cardiology Hospital de Cl\u00ednicas de Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Jos\u00e9 Zimermann","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Federal University of Health Sciences of Porto Alegre and Feevale University Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Abreu","family":"Silva","sequence":"additional","affiliation":[{"name":"Postgraduate Studies Program in Pulmonology School of Medicine Federal University of Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge P.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Cardiology School of Medicine Federal University of Rio Grande do Sul Porto Alegre Brazil"},{"name":"Exercise Pathophysiology Research Laboratory Hospital de Cl\u00ednicas de Porto Alegre Porto Alegre RS Brazil"},{"name":"Department of Cardiology Hospital de Cl\u00ednicas de Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo C.","family":"Berton","sequence":"additional","affiliation":[{"name":"Postgraduate Studies Program in Pulmonology School of Medicine Federal University of Rio Grande do Sul Porto Alegre Brazil"},{"name":"Respiratory Division Hospital de Cl\u00ednicas de Porto Alegre Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0272-5231(21)00928-X","article-title":"Bronchiolitis following infection in adults and children","volume":"14","author":"Penn CC","year":"1993","journal-title":"Clin Chest Med"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70289-1"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.044909"},{"key":"e_1_2_5_5_1","first-page":"453","article-title":"Pulmonary function in children and adolescents with postinfectious bronchiolitis obliterans","volume":"36","author":"Matiello R","year":"2010","journal-title":"J Bras Pneumol"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.4.1101"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20784"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200301-053SO"},{"key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2223\/JPED.1807","article-title":"Functional capacity assessment during exercise in children and adolescents with post\u2010infectious bronchiolitis obliterans","volume":"84","author":"Mattiello R","year":"2008","journal-title":"J Pediatr (Rio J)"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.2223\/JPED.49"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(200005)29:5<341::AID-PPUL2>3.0.CO;2-4"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2010.07.005"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.85.6.751"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00035005"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034905"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1969.26.3.308"},{"key":"e_1_2_5_18_1","first-page":"87","volume-title":"Pulmonary function testing in children: techniques and standards","author":"Polgar G","year":"1971"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198205000-00012"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1984.129.2P2.S49"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.116.2.488"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198409000-00008"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.167.2.211"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1249\/00003677-199401000-00016"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10097"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00040506"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.01946"},{"key":"e_1_2_5_28_1","first-page":"376","article-title":"Clinical significance of lung perfusion defects in children with post\u2010infectious bronchiolitis obliterans","volume":"57","author":"Y\u00fcksel H","year":"2009","journal-title":"Tuberk Toraks"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-34817-9_3"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2007.01209.x"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.22929","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.22929","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T22:37:17Z","timestamp":1696459037000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.22929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,23]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1002\/ppul.22929"],"URL":"https:\/\/doi.org\/10.1002\/ppul.22929","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,23]]}}}