{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:26:15Z","timestamp":1762503975048},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T00:00:00Z","timestamp":1386720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Rationale<\/jats:title><jats:p>High\u2010resolution computed tomography (HRCT) plays an important role in the diagnosis and staging of pulmonary sarcoidosis, but implies radiation exposure. In this light, we aimed to describe HRCT findings as well as their relationship with pulmonary function tests (PFT) in children with pulmonary sarcoidosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a retrospective study, 18 pediatric patients with sarcoidosis, including 12 with pulmonary abnormalities (PA group) and 6 without pulmonary abnormalities (APA group) were followed over a 16\u2010year period. Relationships between HRCT scores and PFT were studied by non\u2010parametric Spearman's test at diagnosis and by restricted maximum likelihood (REML) analysis during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010three HRCT were scored. Twelve patients showed abnormal HRCT findings at diagnosis with multiple nodules or micronodules, while ground\u2010glass opacities were seen in 11 patients. Ten patients exhibited pleural thickening or thickening of the fissure and 6 had interlobular septal thickening at diagnosis. No correlation between HRCT and forced vital capacity (FVC), forced expiratory volume in 1\u2009sec (FEV<jats:sub>1<\/jats:sub>), forced expiratory flow during the mid\u2010half of the FVC (FEF<jats:sub>25\u201375<\/jats:sub>) and specific dynamical compliance (SpecC<jats:sub>Ldyn<\/jats:sub>) was found at diagnosis. However, linear mixed models showed that changes in total HRCT scores over time were significantly associated with SpecC<jats:sub>Ldyn<\/jats:sub>, FVC, and FEV<jats:sub>1<\/jats:sub> modifications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Radiologic findings in children with pulmonary sarcoidosis were similar to those in adults. HRCT and PFT are both essential investigations at diagnosis; however, the correlation between HRCT pulmonary parenchymal findings and PFT over time suggests the possibility of reducing the number of HRCT during follow\u2010up to decrease unnecessary radiation exposure. <jats:bold>Pediatr Pulmonol. 2014; 49:1223\u20131233.<\/jats:bold> \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.22956","type":"journal-article","created":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T14:12:52Z","timestamp":1386771172000},"page":"1223-1233","source":"Crossref","is-referenced-by-count":24,"title":["Sarcoidosis in children: HRCT findings and correlation with pulmonary function tests"],"prefix":"10.1002","volume":"49","author":[{"given":"C.","family":"Sileo","sequence":"first","affiliation":[{"name":"Universit\u00e9 Pierre et Marie Curie Paris France"},{"name":"AP\u2010HP H\u00f4pital Armand Trousseau Service de Radiologie P\u00e9diatrique Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Epaud","sequence":"additional","affiliation":[{"name":"Centre Intercommunal de Cr\u00e9teil Service de P\u00e9diatrie Cr\u00e9teil France"},{"name":"Inserm U955 Cr\u00e9teil France"},{"name":"Universit\u00e9 Paris\u2010Est Facult\u00e9 de M\u00e9decine Cr\u00e9teil France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Respiratoires Rares Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mahloul","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence des Maladies Respiratoires Rares Paris France"},{"name":"INSERM UMR_S707 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Beydon","sequence":"additional","affiliation":[{"name":"AP\u2010HP H\u00f4pital Armand Trousseau Unit\u00e9 Fonctionnelle de Physiologie\u2014Explorations Fonctionnelles Respiratoires Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Elia","sequence":"additional","affiliation":[{"name":"AP\u2010HP H\u00f4pital Armand Trousseau Service de Radiologie P\u00e9diatrique Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Clement","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Pierre et Marie Curie Paris France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Respiratoires Rares Paris France"},{"name":"AP\u2010HP H\u00f4pital Armand Trousseau Service de Pneumologie P\u00e9diatrique Paris France"},{"name":"INSERM UMR_S U893 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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