{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T11:13:03Z","timestamp":1772449983960,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,17]],"date-time":"2013-12-17T00:00:00Z","timestamp":1387238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006706","name":"Tampere Tuberculosis Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006706","id-type":"DOI","asserted-by":"crossref"}]},{"name":"North-Karelia Central Hospital, Joensuu, Finland"},{"name":"The National Graduation School of Clinical Investigations"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of the study was to evaluate the association between previous use of ICS and bone mineral density (BMD) at school age in a cohort followed after early childhood wheezing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>As part of a prospective follow\u2010up study after hospitalization for wheezing at &lt;24 months of age, BMD was measured in 89 children at 12.3 (median) years of age. Data on ICS use were collected by interviewing the parents, and this was supplemented with data from patient records. Cumulative doses and the duration of ICS use were calculated. Areal BMD (BMD<jats:sub>areal<\/jats:sub>, g\/cm<jats:sup>2<\/jats:sup>) was measured by dual energy X\u2010ray absorptiometry (DXA), and apparent volumetric BMD (aBMD<jats:sub>vol<\/jats:sub>, g\/cm<jats:sup>3<\/jats:sup>) was calculated, for the lumbar spine and femoral neck. Weight, height and pubertal stage were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>Age, sex, and pubertal stage were significantly associated with BMD<jats:sub>areal<\/jats:sub> and aBMD<jats:sub>vol<\/jats:sub> of the lumbar spine and BMD<jats:sub>areal<\/jats:sub> of the femoral neck. The regular use of ICS for &gt;6 months at age &lt;6 years was associated with a lower BMD of the lumbar spine. A lower BMD<jats:sub>areal<\/jats:sub> and aBMD<jats:sub>vol<\/jats:sub> of the femoral neck were associated with higher cumulative doses of ICS at age 0\u201312.3 (median) years. The results were robust to adjustment for age, sex, pubertal stage, height, weight, and use of systemic steroids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ICS use during childhood may be related to a decrease in BMD at late school age. It is important to use the lowest possible ICS dose that maintains adequate asthma control. <jats:bold>Pediatr Pulmonol. 2015; 50:1\u20137.<\/jats:bold> \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.22968","type":"journal-article","created":{"date-parts":[[2013,12,17]],"date-time":"2013-12-17T14:28:42Z","timestamp":1387290522000},"page":"1-7","source":"Crossref","is-referenced-by-count":20,"title":["Inhaled corticosteroids and bone mineral density at school age: A follow\u2010up study after early childhood wheezing"],"prefix":"10.1002","volume":"50","author":[{"given":"Virpi H.","family":"Sidoroff","sequence":"first","affiliation":[{"name":"Department of Paediatrics School of Medicine University of Eastern Finland Kuopio Finland"},{"name":"Department of Paediatrics North\u2010Karelia Central Hospital Joensuu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari K.","family":"Ylinen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Kuopio University Hospital Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liisa M.","family":"Kr\u00f6ger","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Kuopio University Hospital Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heikki P.J.","family":"Kr\u00f6ger","sequence":"additional","affiliation":[{"name":"Department of Surgery Kuopio University Hospital Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matti O.","family":"Korppi","sequence":"additional","affiliation":[{"name":"Department of Paediatrics School of Medicine University of Eastern Finland Kuopio Finland"},{"name":"Paediatric Research Centre Tampere University and University Hospital Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.11.050"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02307.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.6.e706"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.169177"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(03)01859-1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.6.2329"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203229"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.1.8542121"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.1.9707072"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2005.04.013"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(200003)29:3<188::AID-PPUL6>3.0.CO;2-K"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-3381"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1913"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2057"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-007-0786-4"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1996.02170300066013"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.2002.02091.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20273"},{"key":"e_1_2_7_20_1","unstructured":"Northwest institute for bio\u2010health informatics. 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