{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:06:50Z","timestamp":1773281210758,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,1,14]],"date-time":"2014-01-14T00:00:00Z","timestamp":1389657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study was performed to examine the effectiveness and safety of oral sildenafil and inhaled iloprost in term newborns with persistent pulmonary hypertension of the newborn (PPHN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Oral sildenafil and inhaled iloprost were administered to 27 and 20 neonates, respectively, for treatment of persistent pulmonary hypertension. All patients were term infants at 37 gestational weeks or older. In the sildenafil group, 14 patients had meconium aspiration syndrome, 8 had asphyxia (hypoxic ischemic encephalopathy stages II and III), 3 had congenital pneumonia, 1 had transient tachypnea, and 1 had idiopathic PPHN. In the iloprost group, 9 patients had meconium aspiration syndrome, 7 had asphyxia (hypoxic ischemic encephalopathy stages II and III), 3 had congenital pneumonia, and 1 had transient tachypnea. Sildenafil citrate was administered via an oral feeding tube. Iloprost was administered endotracheally to patients on mechanical ventilation using a jet nebulizer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Iloprost appeared to be more effective than sildenafil in the treatment of PPHN with regard to time to adequate clinical response, ventilatory parameters, duration of drug administration, duration of mechanical ventilation, duration of return to normal values of respiratory failure indices, use of MgSO<jats:sub>4<\/jats:sub> as a second vasodilator and requirement for support with inotropic agents. We observed no side effects on blood pressure or homeostasis in any of the patients in the iloprost group. Systemic hypotension was significantly elevated in the sildenafil group. Four and three infants died of PPHN in the sildenafil and iloprost groups, respectively. Pulmonary systolic arterial pressure decreased to normal levels in the remaining 40 patients, and they were discharged from hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We suggested that inhaled iloprost may be a safe and effective treatment choice in newborn infants with persistent pulmonary hypertension. In cases where treatment with inhaled iloprost, ECMO or INO is not possible, oral sildenafil can be an alternative therapy option in the treatment of PPHN. <jats:bold>Pediatr Pulmonol. 2014; 49:1205\u20131213.<\/jats:bold> \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.22985","type":"journal-article","created":{"date-parts":[[2014,1,14]],"date-time":"2014-01-14T09:01:25Z","timestamp":1389690085000},"page":"1205-1213","source":"Crossref","is-referenced-by-count":48,"title":["Oral sildenafil and inhaled iloprost in the treatment of pulmonary hypertension of the newborn"],"prefix":"10.1002","volume":"49","author":[{"given":"Hasan","family":"Kahveci","sequence":"first","affiliation":[{"name":"Division of Neonatal Intensive Care Unit Erzurum District Training and Research Hospital Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Erzurum District Training and Research Hospital Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ummu Zeynep","family":"Avsar","sequence":"additional","affiliation":[{"name":"Department of Medical Education Ataturk University Medical Faculty Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Ciftel","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Erzurum District Training and Research Hospital Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer","family":"Kilic","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases Erzurum District Training and Research Hospital Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuat","family":"Laloglu","sequence":"additional","affiliation":[{"name":"Division of Neonatal Intensive Care Unit Nenehatun Obstetrics and Gynecology Hospital Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kezban","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Erzurum District Training and Research Hospital Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/00148581-200608030-00004"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/138955708786786507"},{"key":"e_1_2_6_4_1","first-page":"408","article-title":"Intravenous prostacyclin in the treatment of persistent pulmonary hypertension of the newborn refractory to inhaled nitric oxide","volume":"7","author":"Golzand E","year":"2005","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.06.012"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/50.4.219"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10389"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1239496"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmq091"},{"key":"e_1_2_6_10_1","first-page":"325","article-title":"Review of inhaled iloprost for the control of pulmonary artery hypertension in children","volume":"5","author":"Tissot C","year":"2009","journal-title":"Vasc Health Risk Manag"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951103000726"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","unstructured":"EifingerF SreeramN MehlerK HuenselerC KribsA RothB. 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