{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:38:06Z","timestamp":1787506686602,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,4,11]],"date-time":"2014-04-11T00:00:00Z","timestamp":1397174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Pulmonary hypertension (PH) in children is a serious disorder, for which the major goal of treatment is to prevent progressive vascular remodeling, and improve clinical status and survival. Iloprost is approved for the treatment of PH in adults; however, few studies have evaluated its effects in children. The objective of this study is to analyze the long\u2010term effects of inhaled iloprost treatment in children with PH. A retrospective study was conducted in patients treated with iloprost between 2000 and 2012. Patients with left\u2013right cardiac shunt and persistent PH of the newborn were excluded. The cohort comprised 22 patients (15 females) with a median age of 2.6 years. Twelve patients had pulmonary arterial hypertension including idiopathic (n\u2009=\u20096), hereditary (n\u2009=\u20092) and associated (congenital heart disease [n\u2009=\u20093], and schistosomiasis [n\u2009=\u20091]). One patient had pulmonary veno\u2010occlusive disease, six patients had PH secondary to lung disease and three had multifactorial PH. Median mean pulmonary arterial pressure was 55\u2009mmHg and median pulmonary vascular resistance was 15.5\u2009Wood units. Good tolerability was observed, with the exception of one case of recurring abdominal pain. PH resolved in two patients, with functional capacity improvement in 10 patients and stabilization in three patients. The clinical condition of six patients deteriorated; two died, and two received lung transplants. In conclusion, the results of this uncontrolled study showed that iloprost was effective and well tolerated in children. However, further research is needed to support this study, as PH is a serious condition that can require organ transplantation or result in death.\n                      <jats:bold>Pediatr Pulmonol. 2015; 50:370\u2013379.<\/jats:bold>\n                      \u00a9 2014 Wiley Periodicals, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.23044","type":"journal-article","created":{"date-parts":[[2014,4,11]],"date-time":"2014-04-11T14:46:55Z","timestamp":1397227615000},"page":"370-379","source":"Crossref","is-referenced-by-count":8,"title":["Use of inhaled iloprost in children with pulmonary hypertension"],"prefix":"10.1002","volume":"50","author":[{"given":"Antonio","family":"Moreno\u2010Gald\u00f3","sequence":"first","affiliation":[{"name":"Unidad de Neumolog\u00eda Pedi\u00e1trica y Fibrosis Qu\u00edstica Hospital Universitari Vall d'Hebron, Universitat Aut\u00f2noma de Barcelona Barcelona 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Gran","family":"Pi\u00f1a","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Cardiolog\u00eda Pedi\u00e1trica Hospital Universitari Vall d'Hebron, Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Gartner","sequence":"additional","affiliation":[{"name":"Unidad de Neumolog\u00eda Pedi\u00e1trica y Fibrosis Qu\u00edstica Hospital Universitari Vall d'Hebron, Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimpna Albert","family":"Brotons","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Cardiolog\u00eda Pedi\u00e1trica Hospital Universitari Vall d'Hebron, Universitat Aut\u00f2noma de Barcelona Barcelona 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