{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:44:19Z","timestamp":1787856259725,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,5,22]],"date-time":"2014-05-22T00:00:00Z","timestamp":1400716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"March of Dimes Grant","award":["06-FY08-264"],"award-info":[{"award-number":["06-FY08-264"]}]},{"name":"National Institutes of Health (NIH) Grant","award":["HL-067392"],"award-info":[{"award-number":["HL-067392"]}]},{"name":"National Institutes of Health (NIH) Grant","award":["HL-091968"],"award-info":[{"award-number":["HL-091968"]}]},{"name":"National Institutes of Health (NIH) Grant","award":["HL-097141"],"award-info":[{"award-number":["HL-097141"]}]},{"name":"NIH Training Grant","award":["HD-057821"],"award-info":[{"award-number":["HD-057821"]}]},{"name":"NIH Training Grant","award":["ES-07026"],"award-info":[{"award-number":["ES-07026"]}]},{"name":"NIH Training Grant","award":["HL-66988"],"award-info":[{"award-number":["HL-66988"]}]},{"name":"Institutional Bradford Scholar Award grant"},{"name":"NIH Center Grant","award":["ES-01247"],"award-info":[{"award-number":["ES-01247"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:label\/><jats:p>An acceptable level of oxygen exposure in preterm infants that maximizes efficacy and minimizes harm has yet to be determined. Quantifying oxygen exposure as an area\u2010under\u2010the curve (O<jats:sub>AUC<\/jats:sub>) has been predictive of later respiratory symptoms among former low birth weight infants. Here, we test the hypothesis that quantifying O<jats:sub>AUC<\/jats:sub> in newborn mice can predict their risk for altered lung development and respiratory viral infections as adults. Newborn mice were exposed to room air or a FiO<jats:sub>2<\/jats:sub> of 100% oxygen for 4 days, 60% oxygen for 8 days, or 40% oxygen for 16 days (same cumulative dose of excess oxygen). At 8 weeks of age, mice were infected intranasally with a non\u2010lethal dose of influenza A virus. Adult mice exposed to 100% oxygen for 4 days or 60% oxygen for 8 days exhibited alveolar simplification and altered elastin deposition compared to siblings birthed into room air, as well as increased inflammation and fibrotic lung disease following viral infection. These changes were not observed in mice exposed to 40% oxygen for 16 days. Our findings in mice support the concept that quantifying O<jats:sub>AUC<\/jats:sub> over a currently unspecified threshold can predict human risk for respiratory morbidity later in life. <jats:bold>Pediatr Pulmonol. 2015; 50:222\u2013230.<\/jats:bold> \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.23063","type":"journal-article","created":{"date-parts":[[2014,5,22]],"date-time":"2014-05-22T08:27:00Z","timestamp":1400747220000},"page":"222-230","source":"Crossref","is-referenced-by-count":17,"title":["Cumulative neonatal oxygen exposure predicts response of adult mice infected with influenza A virus"],"prefix":"10.1002","volume":"50","author":[{"given":"Echezona T.","family":"Maduekwe","sequence":"first","affiliation":[{"name":"Department of Pediatrics, School of Medicine and Dentistry The University of Rochester Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley W.","family":"Buczynski","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, School of Medicine and Dentistry The University of Rochester Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine and Dentistry The University of Rochester Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiruamalai","family":"Rangasamy","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Medicine and Dentistry The University of Rochester Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy P.","family":"Stevens","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine and Dentistry The University of Rochester Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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