{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:31:47Z","timestamp":1767828707061,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,8,18]],"date-time":"2014-08-18T00:00:00Z","timestamp":1408320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Faculty of Medicine, University of Gothenburg"},{"DOI":"10.13039\/501100010234","name":"Swedish Asthma and Allergy Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010234","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:label\/><jats:p>Background: Severe wheezing in early life is associated with an increased risk of asthma during childhood and adolescence. The aim of the present follow\u2010up was to investigate the asthma prevalence and risk factors for asthma in adulthood. Methods: We have prospectively studied asthma development in 101 children hospitalized due to severe wheezing before the age of 24 months. The cohort was re\u2010investigated at a mean age of 27 years and tested for bronchial hyper\u2010responsiveness and allergic sensitization. The response rate in adulthood was 81% (82\/101). The results were compared with a population\u2010based, age\u2010matched control group (n\u2009=\u20091,210) recruited from the West Sweden Asthma Study. Results: Current doctor\u2010diagnosed asthma was found in 37% (30\/82) compared with 7% (82\/1,210) in the control group. The risk of adult asthma in the cohort compared with the control group was increased 10\u2010fold (adjusted OR 10.0, 95% CI 5.3\u201318.7), independently of allergic rhinitis, gender, smoking and heredity. Within the cohort, current allergy (aOR 9.6, 95% CI 3.0\u201331.2) and female gender (aOR 3.2, 95% CI 1.1\u20139.3) independently increased the risk of adult asthma. Females with current allergy had the highest risk of adult asthma (OR 29.4, 95% CI 5.0\u2013173.3), compared with males without allergy. When separately adjusting for factors present at admission in early life within the cohort, a family history of asthma was a significant risk factor for asthma in adulthood (aOR 4.0, 95% CI 1.3\u201312.5). Conclusion: Subjects with severe early wheezing have a 10\u2010fold increase in the risk of adult asthma compared to an age\u2010matched control group, adjusted for allergic rhinitis, gender, smoking and heredity. <jats:bold>Pediatr Pulmonol. 2015; 50:789\u2013797.<\/jats:bold> \u00a9 2014 The Authors. <jats:italic>Pediatric Pulmonology<\/jats:italic> Published by Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.23071","type":"journal-article","created":{"date-parts":[[2014,8,18]],"date-time":"2014-08-18T13:53:00Z","timestamp":1408369980000},"page":"789-797","source":"Crossref","is-referenced-by-count":26,"title":["High risk of adult asthma following severe wheezing in early life"],"prefix":"10.1002","volume":"50","author":[{"given":"Emma","family":"Goks\u00f6r","sequence":"first","affiliation":[{"name":"Department of Paediatrics University of Gothenburg Gothenburg 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