{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T18:49:49Z","timestamp":1767984589875,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T00:00:00Z","timestamp":1403654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institute of Health (NIH) Career Development Award","award":["1K12HL090020\/NHLBI"],"award-info":[{"award-number":["1K12HL090020\/NHLBI"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Despite the many benefits that have been demonstrated by the continuous administration of inhaled corticosteroids (ICS) in persistent asthma, a new strategy for mild\u2010asthma is emerging, consisting of using intermittent or as\u2010needed ICS treatment in conjunction with short\u2010acting beta2 agonists in response to symptoms. However, no previous studies have reported an economic evaluation comparing these two therapeutic strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A Markov\u2010type model was developed in order to estimate costs and health outcomes of a simulated cohort of pediatric patients with persistent asthma treated over a 12\u2010month period. Effectiveness parameters were obtained from a systematic review of the literature. Cost data were obtained from official databases provided by the Colombian Ministry of Health. The main outcome was the variable \u201cquality\u2010adjusted life\u2010years\u201d (QALYs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For the base\u2010case analysis, the model showed that compared to intermittent ICS, daily therapy with ICS had lower costs (US$437.02 vs. 585.03 and US$704.62 vs. 749.81 average cost per patient over 12 months for school children and preschoolers, respectively), and the greatest gain in QALYs (0.9629 vs. 0.9392 QALYs and 0.9238 vs. 0.9130 QALYS for school children and preschoolers, respectively), resulting in daily therapy being considered dominant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present analysis shows that compared to intermittent therapy, daily therapy with ICS for treating pediatric patients with recurrent wheezing and mild persistent asthma is a dominant strategy (more cost effective), because it showed a greater gain in QALYs with lower total treatment costs.<jats:bold>Pediatr Pulmonol. 2015; 50:735\u2013746.<\/jats:bold>\u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.23073","type":"journal-article","created":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T13:42:05Z","timestamp":1403703725000},"page":"735-746","source":"Crossref","is-referenced-by-count":23,"title":["Cost\u2010utility analysis of daily versus intermittent inhaled corticosteroids in mild\u2010persistent asthma"],"prefix":"10.1002","volume":"50","author":[{"given":"Carlos E.","family":"Rodriguez\u2010Martinez","sequence":"first","affiliation":[{"name":"Department of Pediatrics School of Medicine Universidad Nacional de Colombia Bogota Colombia"},{"name":"Research Unit Military Hospital of Colombia Bogota Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Nino","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonary Sleep Medicine and Integrative Systems Biology, Center for Genetic Research, Children's National Medical Center, George Washington University Washington District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose A.","family":"Castro\u2010Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Family Medicine School of Medicine, Pontificia Universidad Catolica de Chile Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200624070-00008"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/142.4.832"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108083250603"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.02.029"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008033430504"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/pai.2007.001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1104647"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62145-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1157\/13120391"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.128486"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-200961"},{"key":"e_1_2_7_13_1","first-page":"268","article-title":"Affordability of inhaled corticosteroids as a potential barrier to treatment of asthma in some developing countries","volume":"4","author":"A\u00eft\u2010Khaled N","year":"2000","journal-title":"Int J Tuberc Lung Dis"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02134.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.116632"},{"key":"e_1_2_7_16_1","first-page":"71","article-title":"Modelos de Markov: Una herramienta \u00fatil para el an\u00e1lisis farmacoecon\u00f3mico","volume":"3","author":"Rubio\u2010Terr\u00e9s C","year":"2006","journal-title":"Pharmacoeconomics \u2010 Spanish Research Articles"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-199813040-00003"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200220030-00004"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2013.767909"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2010.2.1.1"},{"key":"e_1_2_7_21_1","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780198526629.001.0001","volume-title":"Decision modeling for health economic evaluation","author":"Briggs A","year":"2006"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/mzh086"},{"key":"e_1_2_7_23_1","unstructured":"Sistema de Informaci\u00f3n de precios de medicamentos\u2014SISMED. 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