{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T09:41:37Z","timestamp":1770284497207,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T00:00:00Z","timestamp":1404950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Children and adolescents with sickle cell disease (SCD) have a higher incidence of sleep pathology and obstructive sleep apnea syndrome (OSAS). The nocturnal hypoxemia is a risk to vaso\u2010occlusive crisis among other SCD morbidities. Our aim was to compare polysomnography (PSG) results in a sample of children with SCD with a sample of children with suspected OSAS without SCD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Methods<\/jats:title><jats:p>A retrospective study compared clinical and PSG parameters. A descriptive analysis and <jats:italic>t<\/jats:italic>\u2010test were done considering <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 as significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PSG was done in 65 children with SCD and 65 control\u2010children. Control sample was selected to be equal to SCD sample considering gender (53.8% were male), age (mean age was 9.4 years (SD\u2009\u00b1\u20094.6) and AHI (mean 3.57\u2009events\/hr).<\/jats:p><jats:p>Mean efficiency, latency and percentage of sleep phases in both groups showed no statistically significant differences. Mean SpO<jats:sub>2<\/jats:sub> and minimum SpO<jats:sub>2<\/jats:sub> were lower in SCD group and it was statistically significant (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Enuresis was more frequent in the SCD children group (35.4% vs. 6.2%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Comparing children with and without SCD, sleep architecture was similar in both groups and minimum SpO<jats:sub>2<\/jats:sub> was significantly lower in SCD children although both groups had a similar AHI. This is an important issue in these children, so it is essential to have a sleep evaluation in order to prevent complications and co\u2010morbidities. <jats:bold>Pediatr Pulmonol. 2015; 50:396\u2013401.<\/jats:bold> \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.23074","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T16:10:35Z","timestamp":1405008635000},"page":"396-401","source":"Crossref","is-referenced-by-count":16,"title":["Sleep pathology characterization in sickle cell disease: Case\u2013control study"],"prefix":"10.1002","volume":"50","author":[{"given":"Maria In\u00eas","family":"Mascarenhas","sequence":"first","affiliation":[{"name":"Pediatric Department Hospital Prof. Doutor Fernando Fonseca Lisbon Portugal"},{"name":"Sickle Cell Disease Pediatric Group Pediatric Department Hospital Prof. Doutor Fernando Fonseca Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena Cristina","family":"Loureiro","sequence":"additional","affiliation":[{"name":"Pediatric Department Hospital Prof. Doutor Fernando Fonseca Lisbon Portugal"},{"name":"Sickle Cell Disease Pediatric Group Pediatric Department Hospital Prof. Doutor Fernando Fonseca Lisbon Portugal"},{"name":"Pediatric Sleep Laboratory Hospital Prof. Doutor Fernando Fonseca Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Pediatric Department Hospital Prof. Doutor Fernando Fonseca Lisbon Portugal"},{"name":"Sickle Cell Disease Pediatric Group Pediatric Department Hospital Prof. Doutor Fernando Fonseca Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Dias","sequence":"additional","affiliation":[{"name":"Pediatric Department Hospital Prof. Doutor Fernando Fonseca Lisbon Portugal"},{"name":"Sickle Cell Disease Pediatric Group Pediatric Department Hospital Prof. Doutor Fernando Fonseca Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.27880"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31817eb7ef"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21058"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08269.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-007-9018-x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-37132009001100004"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200912-1930OC"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199605000-00007"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.07.007"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-010-1048-4"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200708-138MG"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22564"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199912)28:6<418::AID-PPUL6>3.0.CO;2-D"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.154.9.900"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200109000-00025"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-05-1392"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2013"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.23074","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.23074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T16:10:46Z","timestamp":1696349446000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.23074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,10]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1002\/ppul.23074"],"URL":"https:\/\/doi.org\/10.1002\/ppul.23074","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,10]]}}}