{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:59:10Z","timestamp":1773280750904,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T00:00:00Z","timestamp":1416528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81100458"],"award-info":[{"award-number":["81100458"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate whether nasal intermittent positive pressure ventilation (NIPPV) would decrease the requirement for endotracheal ventilation compared with nasal continuous positive airway pressure(NCPAP) for preterm infants with respiratory distress syndrome (RDS) and compare the related complications between these two noninvasive variations of respiratory support<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A search of major electronic databases, including Medline (1980\u20132013) and the Cochrane Central Register of Controlled Trials, for randomized controlled trials that compared NIPPV versus NCPAP for preterm infants with RDS was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Results<\/jats:title><jats:p>Six randomized controlled trials met selection criteria (n\u2009=\u20091,527). The meta\u2010analyses demonstrated significant decrease in the need for invasive ventilation in the NIPPV group (RR:0.53; 95% CI, 0.33\u20130.85). In the subgroup of infants who received surfactant also demonstrated a significant rate of failure of nasal support in the NIPPV group (RR:0.57; 95% CI 0.42\u20130.78). However, the subgroup of infants whose gestational age (GA)\u2009\u2264\u200930 weeks or birth weight (BW)\u2009&lt;\u20091,500\u2009g showed no difference between the two groups (RR:0.59; 95% CI 0.27\u20131.26); and the subgroup of infants whose GA\u2009&gt;\u200930 weeks or BW\u2009&gt;\u20091,500\u2009g also showed no difference between the two groups (RR:0.63; 95% CI 0.29\u20131.39). No differences in other outcome variables were observed between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among preterm infants with RDS, there was a significant decrease in the need for invasive ventilation in the NIPPV group as compared with NCPAP group, especially for the infants who received surfactant. However, NIPPV could not decrease the need for invasive ventilation both in the subgroup of infants whose GA\u2009\u2264\u200930 weeks or BW\u2009&lt;\u20091,500\u2009g and the subgroup of infants with BW of &gt;30 weeks or BW\u2009&gt;\u20091,500\u2009g. It is limited to analysis the primary outcome generally. Larger trials of this intervention are needed to assess the difference in this primary outcome and the related complications between both forms of noninvasive respiratory support. <jats:bold>Pediatr Pulmonol. 2015; 50:402\u2013409.<\/jats:bold> \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.23130","type":"journal-article","created":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T17:53:21Z","timestamp":1416592401000},"page":"402-409","source":"Crossref","is-referenced-by-count":21,"title":["Nasal intermittent positive pressure ventilation versus nasal continuous positive airway pressure for preterm infants with respiratory distress syndrome: A meta\u2010analysis and up\u2010date"],"prefix":"10.1002","volume":"50","author":[{"given":"Wang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pediatrics Daping Hospital Research Institute of Surgery Third Military Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Daping Hospital Research Institute of Surgery Third Military Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hu","family":"Zhangxue","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Daping Hospital Research Institute of Surgery Third Military Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"Jinning","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Daping Hospital Research Institute of Surgery Third Military Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tang","family":"Shifang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Daping Hospital Research Institute of Surgery Third Military Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma","family":"Juan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Daping Hospital Research Institute of Surgery Third Military Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Renjun","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Daping Hospital Research Institute of Surgery Third Military Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Daping Hospital Research Institute of Surgery Third Military Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,21]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"CD003063","article-title":"Early surfactant administration with brief ventilation vs. selective surfactant and continued mechanical ventilation for preterm infants with or at risk for respiratory distress syndrome (Cochrane review)","volume":"17","author":"Stevens TP","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.118109"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2007.00263.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.04.062"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211381"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2493"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050620"},{"key":"e_1_2_6_9_1","first-page":"3723","article-title":"Surfactant treatment of newborn infants receiving continuous positive airway pressure treatment","volume":"168","author":"Andersen T","year":"2006","journal-title":"Ugeskr Laeger"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(99)00046-8"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.4.638"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.1.13"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2003.tb00472.x"},{"key":"e_1_2_6_14_1","first-page":"CD003212","article-title":"Nasal intermittent positive pressure ventilation (NIPPV) versus nasal continuous positive airway pressure (NCPAP) for preterm neonates after extubation","author":"Davis PG","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7200205"},{"key":"e_1_2_6_16_1","unstructured":"Higgins JPT Green S eds. 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