{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T05:13:15Z","timestamp":1771045995249,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T00:00:00Z","timestamp":1444348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/D070252\/1"],"award-info":[{"award-number":["EP\/D070252\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>With increasing survival of patients with more severe forms of congenital diaphragmatic hernia (CDH) and risk of long\u2010term respiratory morbidity, studies on lung morphology are needed. We used hyperpolarised <jats:sup>3<\/jats:sup>He MRI and anatomical <jats:sup>1<\/jats:sup>H MRI in a cohort of young adult CDH patients to image regional lung ventilation and microstructure, focusing on morphological and micro\u2010structural (alveolar) abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nine patients with left\u2010sided CDH, born 1975\u20131993, were studied. Regional ventilation was imaged with hyperpolarised <jats:sup>3<\/jats:sup>He MRI, and the <jats:sup>3<\/jats:sup>He apparent diffusion coefficient (ADC) was computed separately for the ipsilateral and contralateral lungs. <jats:sup>1<\/jats:sup>H MRI was used to image lung anatomy, total lung volume and motion during free\u2010breathing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:sup>3<\/jats:sup>He MRI showed ventilation abnormalities in six patients, ranging from a single ipsilateral ventilation defect (3 patients) to multiple ventilation defects in both lungs (one patient treated with extra corporeal membrane oxygenation). In eight patients, <jats:sup>3<\/jats:sup>He ADC values for the ipsilateral lung were significantly higher than those for the contralateral lung.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Functional and micro\u2010structural changes persist into adulthood in most CDH patients. Ipsilateral elevated <jats:sup>3<\/jats:sup>He ADC values are consistent with enlargement of mean dimensions of the confining lung micro\u2010structure at the alveolar level. <jats:bold>Pediatr Pulmonol. 2016;51:517\u2013524<\/jats:bold>. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.23325","type":"journal-article","created":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T13:22:54Z","timestamp":1444396974000},"page":"517-524","source":"Crossref","is-referenced-by-count":27,"title":["Pulmonary ventilation and micro\u2010structural findings in congenital diaphragmatic hernia"],"prefix":"10.1002","volume":"51","author":[{"given":"Marjolein","family":"Spoel","sequence":"first","affiliation":[{"name":"Intensive Care and Department of Paediatric Surgery Erasmus MC\u2010Sophia Children's Hospital Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Marshall","sequence":"additional","affiliation":[{"name":"Department of Academic Radiology University of Sheffield Sheffield United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanneke","family":"IJsselstijn","sequence":"additional","affiliation":[{"name":"Intensive Care and Department of Paediatric Surgery Erasmus MC\u2010Sophia Children's Hospital Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Parra\u2010Robles","sequence":"additional","affiliation":[{"name":"Department of Academic Radiology University of Sheffield Sheffield United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Els","family":"van der Wiel","sequence":"additional","affiliation":[{"name":"Department of Paediatrics\u2010Respiratory Medicine and Allergology Erasmus MC\u2010Sophia Children's Hospital 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