{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T14:36:38Z","timestamp":1770906998087,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T00:00:00Z","timestamp":1447891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"None"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Previous studies have suggested that full\u2010term newborns delivered by elective cesarean section who develop transient tachypnea have low gastric microbubble counts. In the present study, microbubble concentrations in oral fluid samples were used to evaluate pulmonary maturity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate lung maturity in full\u2010term newborns delivered by elective caesarean section using the stable microbubble test in oral aspirates collected at birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The study involved newborns with gestational age &gt;37 weeks delivered by elective cesarean section. Oral fluid samples were obtained in the delivery room immediately after birth, and gastric fluid was collected within the first hour of life. Samples were frozen and analyzed by two blinded researchers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The sample comprised 544 newborns. Twenty\u2010two were diagnosed with transient tachypnea of the newborn by the assisting physician, and required admission to the Neonatal Intensive or Intermediate Care Unit. The median (interquartile range) of the number of microbubbles in the oral samples of these patients was 67.5 (45\u2013150) microbubbles\/mm<jats:sup>2<\/jats:sup>. The remaining 498 newborns without respiratory difficulties had a count of 350 (150\u2013750) microbubbles\/mm<jats:sup>2<\/jats:sup>\u2013<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001. Gastric fluid tests revealed a count of 150 (82.5\u2013700) microbubbles\/mm<jats:sup>2<\/jats:sup> for neonates with respiratory difficulties, and of 600 (216\u20131125) microbubbles\/mm<jats:sup>2<\/jats:sup>\u2013<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 for those without respiratory symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present results suggest that transient tachypnea of the newborn is associated with surfactant dysfunction. <jats:bold>Pediatr Pulmonol. 2016;51:596\u2013600<\/jats:bold>. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.23338","type":"journal-article","created":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T19:48:39Z","timestamp":1447962519000},"page":"596-600","source":"Crossref","is-referenced-by-count":9,"title":["Surfactant deficiency in full\u2010term newborns with transient tachypnea delivered by elective 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