{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T07:53:55Z","timestamp":1774079635373,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T00:00:00Z","timestamp":1454976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Izore"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:label\/><jats:p>The effect of viral infection on nasopharyngeal carriage of <jats:italic>Streptococcus pneumoniae<\/jats:italic> during childhood is not well known. We studied dynamics of pneumococcal colonization by quantitative PCR during the natural course of viral bronchiolitis. At time of admission, 47 (47%) of 100 patients with bronchiolitis carried pneumococci. In patients with viral bronchiolitis who did not receive antibiotics, pneumococcal load decreased from time of admission to discharge (n\u2009=\u200935, cycle threshold 23 vs. 25, <jats:italic>P\u2009<\/jats:italic>=\u20090.0017) and from discharge to follow\u2010up (n\u2009=\u200922, cycle threshold 25 vs. 40, <jats:italic>P\u2009<\/jats:italic>=\u20090.003). We conclude that viral respiratory infection is negatively associated with pneumococcal colonization of the upper airways. <jats:bold>Pediatr Pulmonol. 2016;51:863\u2013867<\/jats:bold>. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.23390","type":"journal-article","created":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T15:45:16Z","timestamp":1455032716000},"page":"863-867","source":"Crossref","is-referenced-by-count":4,"title":["Dynamics of nasopharyngeal pneumococcal carriage during the course of viral bronchiolitis"],"prefix":"10.1002","volume":"51","author":[{"given":"Tina E.","family":"Faber","sequence":"first","affiliation":[{"name":"Department of Pediatrics Medical Center Leeuwarden P.O. Box 888 8901 BR Leeuwarden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo A.","family":"Schuurs","sequence":"additional","affiliation":[{"name":"Center for Medical Microbiology and Infectious Diseases Izore Leeuwarden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nic J.G.M.","family":"Veeger","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University Medical Center Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marije P.","family":"Hennus","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care, Wilhelmina Children's Hospital University Medical Center Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis J.","family":"Bont","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Infectious Diseases, Wilhelmina Children's Hospital University Medical Center Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/599828"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-2742"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70342-1"},{"key":"e_1_2_5_5_1","first-page":"336","article-title":"Respiratory syncytial virus infection in young Malaysian children","volume":"40","author":"Chan P","year":"1999","journal-title":"Singapore Med J"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.10.3446-3451.2001"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.3.1374-1382.2000"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.28394-0"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038271"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1077"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000188699.55279.1b"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/529438"},{"key":"e_1_2_5_13_1","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/INF.0b013e3181cdafc2","article-title":"Viral coinfections in children with invasive pneumococcal disease","volume":"29","author":"Techasaensiri B","year":"2010","journal-title":"Pediatr Infect Dis J"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-0507"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000116759.21252.29"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.6.1728"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23291"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02780.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.03.013"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064443"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1290"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31829ec274"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047711"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03480.x"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.23390","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.23390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T14:04:34Z","timestamp":1696514674000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.23390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,9]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1002\/ppul.23390"],"URL":"https:\/\/doi.org\/10.1002\/ppul.23390","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,9]]}}}