{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:27:28Z","timestamp":1791293248997,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"none reported"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Pulmonol."],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1002\/ppul.23488","type":"journal-article","created":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T14:13:25Z","timestamp":1464358405000},"page":"1422-1429","source":"Crossref","is-referenced-by-count":15,"title":["Where does current and future pediatric asthma treatment stand? Remodeling and inflammation: Bird's eye view"],"prefix":"10.1002","volume":"51","author":[{"given":"Ozge","family":"Yilmaz","sequence":"first","affiliation":[{"name":"Department of Pediatric Allergy and Pulmonology; Celal Bayar University Medical Faculty; Manisa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Yuksel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy and Pulmonology; Celal Bayar University Medical Faculty; Manisa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,27]]},"reference":[{"key":"10.1002\/ppul.23488-BIB0001|ppul23488-cit-0001","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jaci.2010.11.037","article-title":"Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome","volume":"127","author":"L\u00f6tvall","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1002\/ppul.23488-BIB0002|ppul23488-cit-0002","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jaci.2011.12.985","article-title":"Asthma outcomes workshop: overview","volume":"129","author":"Busse","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1002\/ppul.23488-BIB0003|ppul23488-cit-0003","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.anai.2012.12.015","article-title":"Role of vascular endothelial growth factor antagonism on airway remodeling in asthma","volume":"110","author":"Yuksel","year":"2013","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1002\/ppul.23488-BIB0004|ppul23488-cit-0004","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1183\/09059180.00004413","article-title":"Tissue remodelling in chronic bronchial diseases: from the epithelial to mesenchymal phenotype","volume":"23","author":"Pain","year":"2014","journal-title":"Eur Respir Rev"},{"key":"10.1002\/ppul.23488-BIB0005|ppul23488-cit-0005","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/ppul.70067","article-title":"Inflammation and airway remodeling","volume":"26","author":"Pohunek","year":"2004","journal-title":"Pediatr Pulmonol Suppl"},{"key":"10.1002\/ppul.23488-BIB0006|ppul23488-cit-0006","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/MCP.0000000000000007","article-title":"Monoclonal antibodies for the treatment of refractory asthma","volume":"20","author":"Hambly","year":"2014","journal-title":"Curr Opin Pulm Med"},{"key":"10.1002\/ppul.23488-BIB0007|ppul23488-cit-0007","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.jaci.2014.01.002","article-title":"Efficacy and safety of an anti-IL-13 mAb in patients with severe asthma: a randomized trial","volume":"133","author":"De Boever","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1002\/ppul.23488-BIB0008|ppul23488-cit-0008","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00005-015-0328-z","article-title":"Prolonged treatment with inhaled corticosteroids does not normalize high activity of matrix metalloproteinase-9 in exhaled breath condensates of children with asthma","volume":"63","author":"Grzela","year":"2015","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"10.1002\/ppul.23488-BIB0009|ppul23488-cit-0009","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1165\/rcmb.2011-0369OC","article-title":"A plasminogen activator inhibitor-1 inhibitor reduces airway remodeling in a murine model of chronic asthma","volume":"46","author":"Lee","year":"2012","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1002\/ppul.23488-BIB0010|ppul23488-cit-0010","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.jaci.2014.05.049","article-title":"Epithelial barrier function: at the front line of asthma immunology and allergic airway inflammation","volume":"134","author":"Georas","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1002\/ppul.23488-BIB0011|ppul23488-cit-0011","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1164\/rccm.200410-1404OC","article-title":"Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction","volume":"171","author":"Saglani","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1002\/ppul.23488-BIB0012|ppul23488-cit-0012","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1165\/rcmb.2014-0290OC","article-title":"Role of matrix metalloproteinases-1 and \u22122 in interleukin-13-suppressed elastin in airway fibroblasts in asthma","volume":"54","author":"Ingram","year":"2016","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1002\/ppul.23488-BIB0013|ppul23488-cit-0013","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1056\/NEJMoa1014350","article-title":"Effect of bronchoconstriction on airway remodeling in asthma","volume":"364","author":"Grainge","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1002\/ppul.23488-BIB0014|ppul23488-cit-0014","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.jaip.2015.05.005","article-title":"Progression of irreversible airflow limitation in asthma: correlation with severe exacerbations","volume":"3","author":"Matsunaga","year":"2015","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1002\/ppul.23488-BIB0015|ppul23488-cit-0015","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1164\/rccm.200205-414OC","article-title":"Early thickening of the reticular basement membrane in children with difficult asthma","volume":"167","author":"Payne","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1002\/ppul.23488-BIB0016|ppul23488-cit-0016","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1164\/rccm.201411-1958OC","article-title":"Airway remodeling in preschool children with severe recurrent wheeze","volume":"192","author":"Lezmi","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1002\/ppul.23488-BIB0017|ppul23488-cit-0017","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1164\/rccm.200707-977OC","article-title":"Increased airway smooth muscle mass in children with asthma, cystic fibrosis, and non-cystic fibrosis bronchiectasis","volume":"177","author":"Regamey","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1002\/ppul.23488-BIB0018|ppul23488-cit-0018","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.jpeds.2008.11.036","article-title":"Long-term budesonide or nedocromil treatment, once discontinued, does not alter the course of mild to moderate asthma in children and adolescents","volume":"154","author":"Strunk","year":"2009","journal-title":"J Pediatr"},{"key":"10.1002\/ppul.23488-BIB0019|ppul23488-cit-0019","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.jaci.2005.07.029","article-title":"Evidence of remodeling in peripheral airways of patients with mild to moderate asthma: effect of hydrofluoroalkane-flunisolide","volume":"116","author":"Bergeron","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1002\/ppul.23488-BIB0020|ppul23488-cit-0020","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s12325-008-0048-4","article-title":"Budesonide\/formoterol decreases expression of vascular endothelial growth factor (VEGF) and VEGF receptor 1 within airway remodelling in asthma","volume":"25","author":"Wang","year":"2008","journal-title":"Adv Ther"},{"key":"10.1002\/ppul.23488-BIB0021|ppul23488-cit-0021","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/ppul.20067","article-title":"Reduced eosinophil pro-fibrogenic effect in severe childhood asthma compared to mild disease: an effect of corticosteroids","volume":"38","author":"Puxeddu","year":"2004","journal-title":"Pediatr Pulmonol"},{"key":"10.1002\/ppul.23488-BIB0022|ppul23488-cit-0022","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1067\/mai.2003.1557","article-title":"Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression","volume":"111","author":"Chakir","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1002\/ppul.23488-BIB0023|ppul23488-cit-0023","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1164\/ajrccm.159.4.9806052","article-title":"Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment. The AMPUL Study Group","volume":"159","author":"Sont","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1002\/ppul.23488-BIB0024|ppul23488-cit-0024","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1056\/NEJMoa1014350","article-title":"Effect of bronchoconstriction on airway remodeling in asthma","volume":"364","author":"Grainge","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1002\/ppul.23488-BIB0025|ppul23488-cit-0025","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/s11882-014-0484-y","article-title":"Anticholinergics\/antimuscarinic drugs in asthma","volume":"14","author":"Soler","year":"2014","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1002\/ppul.23488-BIB0026|ppul23488-cit-0026","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.tips.2014.11.005","article-title":"Acetylcholine beyond bronchoconstriction: roles in inflammation and remodeling","volume":"36","author":"Kistemaker","year":"2015","journal-title":"Trends Pharmacol Sci"},{"key":"10.1002\/ppul.23488-BIB0027|ppul23488-cit-0027","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1165\/rcmb.2013-0220OC","article-title":"Muscarinic M3 receptors contribute to allergen-induced airway remodeling in mice","volume":"50","author":"Kistemaker","year":"2014","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1002\/ppul.23488-BIB0028|ppul23488-cit-0028","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1165\/rcmb.2012-0261OC","article-title":"Cross-talk between transforming growth factor-\u03b21 and muscarinic M2 receptors augments airway smooth muscle proliferation","volume":"49","author":"Oenema","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1002\/ppul.23488-BIB0029|ppul23488-cit-0029","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/BF03256642","article-title":"Acute asthma in children and adolescents: should inhaled anticholinergics be added to beta(2)-agonists","volume":"2","author":"Plotnick","year":"2003","journal-title":"Am J Respir Med"},{"key":"10.1002\/ppul.23488-BIB0030|ppul23488-cit-0030","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.pupt.2012.07.003","article-title":"Muscarinic receptors on airway mesenchymal cells: novel findings for an ancient target","volume":"26","author":"Meurs","year":"2013","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1002\/ppul.23488-BIB0031|ppul23488-cit-0031","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.intimp.2013.09.017","article-title":"Effects of montelukast on subepithelial\/peribronchial fibrosis in a murine model of ovalbumin induced chronic asthma","volume":"17","author":"Shin","year":"2013","journal-title":"Int Immunopharmacol"},{"key":"10.1002\/ppul.23488-BIB0032|ppul23488-cit-0032","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.bbrc.2014.05.033","article-title":"Montelukast suppresses epithelial to mesenchymal transition of bronchial epithelial cells induced by eosinophils","volume":"449","author":"Hosoki","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1002\/ppul.23488-BIB0033|ppul23488-cit-0033","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1465-9921-9-44","article-title":"Synthesis of tenascin and laminin beta2 chain in human bronchial epithelial cells is enhanced by cysteinyl leukotrienes via CysLT1 receptor","volume":"9","author":"Altraja","year":"2008","journal-title":"Respir Res"},{"key":"10.1002\/ppul.23488-BIB0034|ppul23488-cit-0034","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00408-010-9227-6","article-title":"Corticosteroids and montelukast: effects on airway epithelial and human umbilical vein endothelial cells","volume":"188","author":"Andersson","year":"2010","journal-title":"Lung"},{"key":"10.1002\/ppul.23488-BIB0035|ppul23488-cit-0035","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1164\/rccm.200501-088OC","article-title":"Reversal of allergen-induced airway remodeling by CysLT1 receptor blockade","volume":"173","author":"Henderson","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1002\/ppul.23488-BIB0036|ppul23488-cit-0036","first-page":"CD009585","article-title":"Addition of anti-leukotriene agents to inhaled corticosteroids in children with persistent asthma","volume":"10","author":"Chauhan","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1002\/ppul.23488-BIB0037|ppul23488-cit-0037","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.anai.2011.01.017","article-title":"Intermittent or daily montelukast versus placebo for episodic asthma in children","volume":"106","author":"Valovirta","year":"2011","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1002\/ppul.23488-BIB0038|ppul23488-cit-0038","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jaci.2006.09.042","article-title":"Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: the Pediatric Asthma Controller Trial","volume":"119","author":"Sorkness","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1002\/ppul.23488-BIB0039|ppul23488-cit-0039","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jaip.2012.08.005","article-title":"Budesonide inhalation suspension versus montelukast in children aged 2 to 4 years with mild persistent asthma","volume":"1","author":"Szefler","year":"2013","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1002\/ppul.23488-BIB0040|ppul23488-cit-0040","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2500\/aap.2011.32.3482","article-title":"Onset and duration of attenuation of exercise-induced bronchoconstriction in children by single-dose of montelukast","volume":"32","author":"Wasfi","year":"2011","journal-title":"Allergy Asthma Proc"},{"key":"10.1002\/ppul.23488-BIB0041|ppul23488-cit-0041","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.intimp.2013.08.021","article-title":"Comparison of TNF antagonism by etanercept and dexamethasone on airway epithelium and remodeling in an experimental model of asthma","volume":"17","author":"Yilmaz","year":"2013","journal-title":"Int Immunopharmacol"},{"key":"10.1002\/ppul.23488-BIB0042|ppul23488-cit-0042","first-page":"2954","article-title":"TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice","volume":"119","author":"Baluk","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1002\/ppul.23488-BIB0043|ppul23488-cit-0043","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1164\/rccm.200809-1512OC","article-title":"A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma","volume":"179","author":"Wenzel","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1002\/ppul.23488-BIB0044|ppul23488-cit-0044","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1183\/09031936.00063510","article-title":"Efficacy and safety of etanercept in moderate-to-severe asthma: a randomised, controlled trial","volume":"37","author":"Holgate","year":"2011","journal-title":"Eur Respir J"},{"key":"10.1002\/ppul.23488-BIB0045|ppul23488-cit-0045","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/imm.12355","article-title":"IgE\/antigen-mediated enhancement of IgE production is a mechanism underlying the exacerbation of airway inflammation and remodeling in mice","volume":"144","author":"Mizutani","year":"2014","journal-title":"Immunology"},{"key":"10.1002\/ppul.23488-BIB0046|ppul23488-cit-0046","doi-asserted-by":"crossref","first-page":"e56015","DOI":"10.1371\/journal.pone.0056015","article-title":"The role of IgE-receptors in IgE-dependent airway smooth muscle cell remodelling","volume":"8","author":"Roth","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1002\/ppul.23488-BIB0047|ppul23488-cit-0047","doi-asserted-by":"crossref","first-page":"e0136549","DOI":"10.1371\/journal.pone.0136549","article-title":"Serum IgE induced airway smooth muscle cell remodeling is independent of allergens and is prevented by omalizumab","volume":"10","author":"Roth","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1002\/ppul.23488-BIB0048|ppul23488-cit-0048","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1159\/000334701","article-title":"Effects of adding omalizumab, an anti-immunoglobulin E antibody, on airway wall thickening in asthma","volume":"83","author":"Hoshino","year":"2012","journal-title":"Respiration"},{"key":"10.1002\/ppul.23488-BIB0049|ppul23488-cit-0049","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2500\/aap.2014.35.3741","article-title":"The effect of omalizumab on small airway inflammation as measured by exhaled nitric oxide in moderate-to-severe asthmatic patients","volume":"35","author":"Pasha","year":"2014","journal-title":"Allergy Asthma Proc"},{"key":"10.1002\/ppul.23488-BIB0050|ppul23488-cit-0050","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1111\/j.1398-9995.2009.02201.x","article-title":"Effects of omalizumab on markers of inflammation in patients with allergic asthma","volume":"64","author":"Holgate","year":"2009","journal-title":"Allergy"},{"key":"10.1002\/ppul.23488-BIB0051|ppul23488-cit-0051","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.1398-9995.2004.00770.x","article-title":"The effect of treatment with omalizumab, an anti-IgE antibody, on asthma exacerbations and emergency medical visits in patients with severe persistent asthma","volume":"60","author":"Bousquet","year":"2005","journal-title":"Allergy"},{"key":"10.1002\/ppul.23488-BIB0052|ppul23488-cit-0052","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.imlet.2014.08.010","article-title":"Proteomics of bronchial biopsies: galectin-3 as a predictive biomarker of airway remodelling modulation in omalizumab-treated severe asthma patients","volume":"162","author":"Mauri","year":"2014","journal-title":"Immunol Lett"},{"key":"10.1002\/ppul.23488-BIB0053|ppul23488-cit-0053","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.jaci.2013.05.020","article-title":"Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia","volume":"132","author":"Laviolette","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1002\/ppul.23488-BIB0054|ppul23488-cit-0054","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1056\/NEJMoa1403290","article-title":"Mepolizumab treatment in patients with severe eosinophilic asthma","volume":"371","author":"Ortega","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1002\/ppul.23488-BIB0055|ppul23488-cit-0055","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S2213-2600(15)00042-9","article-title":"Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials","volume":"3","author":"Castro","year":"2015","journal-title":"Lancet Respir Med"},{"key":"10.1002\/ppul.23488-BIB0056|ppul23488-cit-0056","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1002\/jcp.24814","article-title":"Vitamin D attenuates cytokine-induced remodeling in human fetal airway smooth muscle cells","volume":"230","author":"Britt","year":"2015","journal-title":"J Cell Physiol"},{"key":"10.1002\/ppul.23488-BIB0057|ppul23488-cit-0057","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1164\/rccm.201107-1239OC","article-title":"Relationship between serum vitamin D, disease severity, and airway remodeling in children with asthma","volume":"184","author":"Gupta","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1002\/ppul.23488-BIB0058|ppul23488-cit-0058","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jaci.2010.03.043","article-title":"Serum vitamin d levels and severe asthma exacerbations in the childhood asthma management program study","volume":"126","author":"Brehm","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1002\/ppul.23488-BIB0059|ppul23488-cit-0059","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1164\/rccm.201202-0351OC","article-title":"Effect of vitamin D and inhaled corticosteroid treatment on lung function in children","volume":"186","author":"Wu","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1002\/ppul.23488-BIB0060|ppul23488-cit-0060","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.anai.2012.12.015","article-title":"Role of vascular endothelial growth factor antagonism on airway remodeling in asthma","volume":"110","author":"Yuksel","year":"2013","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1002\/ppul.23488-BIB0061|ppul23488-cit-0061","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1084\/jem.20070956","article-title":"Bronchial smooth muscle remodeling involves calcium-dependent enhanced mitochondrial biogenesis in asthma","volume":"204","author":"Trian","year":"2007","journal-title":"J Exp Med"},{"key":"10.1002\/ppul.23488-BIB0062|ppul23488-cit-0062","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.pupt.2009.12.005","article-title":"Promoting effects of IL-13 on Ca2+ release and store-operated Ca2+ entry in airway smooth muscle cells","volume":"23","author":"Gao","year":"2010","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1002\/ppul.23488-BIB0063|ppul23488-cit-0063","first-page":"167","article-title":"New insights into the treatment of severe asthma in children","volume":"16","author":"Giovannini-Chami","year":"2015","journal-title":"Paediatr Respir Rev"},{"key":"10.1002\/ppul.23488-BIB0064|ppul23488-cit-0064","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1056\/NEJMoa1304048","article-title":"Dupilumab in persistent asthma with elevated eosinophil levels","volume":"368","author":"Wenzel","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1002\/ppul.23488-BIB0065|ppul23488-cit-0065","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1183\/09031936.00223411","article-title":"A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma","volume":"41","author":"Piper","year":"2013","journal-title":"Eur Respir J"},{"key":"10.1002\/ppul.23488-BIB0066|ppul23488-cit-0066","doi-asserted-by":"crossref","first-page":"e0121615","DOI":"10.1371\/journal.pone.0121615","article-title":"IMD-4690, a novel specific inhibitor for plasminogen activator inhibitor-1, reduces allergic airway remodeling in a mouse model of chronic asthma via regulating angiogenesis and remodeling-related mediators","volume":"10","author":"Tezuka","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1002\/ppul.23488-BIB0067|ppul23488-cit-0067","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jaci.2013.09.002","article-title":"Childhood asthma clusters and response to therapy in clinical trials","volume":"133","author":"Chang","year":"2014","journal-title":"J Allergy Clin Immunol"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.23488","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.23488","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/ppul.23488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T22:03:36Z","timestamp":1625349816000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.23488"}},"subtitle":["Pediatric Asthma, Inflammation, and Remodeling"],"short-title":[],"issued":{"date-parts":[[2016,5,27]]},"references-count":67,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"URL":"https:\/\/doi.org\/10.1002\/ppul.23488","archive":["Portico"],"relation":{},"ISSN":["8755-6863"],"issn-type":[{"value":"8755-6863","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5,27]]}}}