{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T19:39:25Z","timestamp":1771270765099,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T00:00:00Z","timestamp":1476403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck & Co., Inc","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Mometasone furoate (MF), delivered via dry\u2010powder inhaler (DPI) QD in the evening (PM), is a treatment option for pediatric patients with asthma. We evaluated MF delivered via a metered\u2010dose inhaler (MDI), in children ages 5\u201311 years with persistent asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a 12\u2010week double\u2010blind, double\u2010dummy, placebo\u2010controlled trial. Pateints were randomized to the following treatments: MF\u2010MDI 50\u2009mcg BID, MF\u2010MDI 100\u2009mcg BID, MF\u2010MDI 200\u2009mcg BID, MF\u2010DPI 100\u2009mcg QD PM, and placebo. The primary analysis assessed MF\u2010MDI doses versus placebo, on the change in %\u2010predicted forced expiratory volume in one second (FEV<jats:sub>1<\/jats:sub>) from baseline to week\u201012; a secondary analysis compared MF\u2010MDI 50\u2009mcg BID versus MF\u2010DPI 100\u2009mcg QD PM. Adverse events (AEs) were monitored throughout the trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For change from baseline in %\u2010predicted FEV<jats:sub>1<\/jats:sub> at week 12, least\u2010squares (LS) mean differences from placebo were 3.87 (<jats:italic>P<\/jats:italic>\u2009=\u20090.019), 6.29 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and 5.34 (<jats:italic>P<\/jats:italic>\u2009=\u20090.001) percentage\u2010points for MF\u2010MDI 50, 100, and 200\u2009mcg BID, respectively. The LS mean difference for MF\u2010MDI 50\u2009mcg BID versus MF\u2010DPI 100\u2009mcg QD PM was 1.39 (<jats:italic>P<\/jats:italic>\u2009=\u20090.368). AE incidences were similar among all treatment groups. There were no reports of oropharyngeal candidiasis or dysphonia, which were AEs pre\u2010specified for analysis,.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In children ages 5\u201311 years with persistent asthma, all three doses of MF\u2010MDI (50, 100, and 200\u2009mcg BID) demonstrated significant improvement in FEV<jats:sub>1<\/jats:sub> after 12 weeks of treatment. MF was generally well tolerated with no new safety concerns identified in this trial. <jats:bold>Pediatr Pulmonol. 2017;52:310\u2013318.<\/jats:bold> \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.23563","type":"journal-article","created":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T13:54:43Z","timestamp":1476453283000},"page":"310-318","source":"Crossref","is-referenced-by-count":11,"title":["Mometasone furoate (MF) improves lung function in pediatric asthma: A double\u2010blind, randomized controlled dose\u2010ranging trial of MF metered\u2010dose inhaler"],"prefix":"10.1002","volume":"52","author":[{"given":"Niran J.","family":"Amar","sequence":"first","affiliation":[{"name":"Allergy &amp; Asthma Research Institute Waco Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tulin","family":"Shekar","sequence":"additional","affiliation":[{"name":"Merck &amp; Co., Inc. Kenilworth New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracey A.","family":"Varnell","sequence":"additional","affiliation":[{"name":"Merck &amp; Co., Inc. Kenilworth New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anish","family":"Mehta","sequence":"additional","affiliation":[{"name":"Merck &amp; Co., Inc. Kenilworth New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Philip","sequence":"additional","affiliation":[{"name":"Merck &amp; Co., Inc. Kenilworth New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra054308"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.04.042"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.12010221"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.5.9706116"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.00001.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00138707"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1368-5031.2006.00798.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2011.630390"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61099-X"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2165\/11316220-000000000-00000"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.109431"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62275-2"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1G410"},{"key":"e_1_2_6_15_1","unstructured":"Global Initiative for Asthma (GINA) NHLaBIGSfAMaP. National Asthma Education and Prevention Program (NAEPP).Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma (updated 2011). 7 A.D."},{"key":"e_1_2_6_16_1","unstructured":"American Thoracic Society. ATS Documents: Statements Guidelines & Reports: ATS\/ERS standardisation of lung functioning testing: Standardisation of spirometry.2005."},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-9-43"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.2.652"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2011.604883"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62140-0"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.105709"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.4.2007063"}],"updated-by":[{"DOI":"10.1002\/ppul.24291","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T00:00:00Z","timestamp":1553472000000}}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.23563","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.23563","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.23563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T13:25:20Z","timestamp":1696512320000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.23563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,14]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1002\/ppul.23563"],"URL":"https:\/\/doi.org\/10.1002\/ppul.23563","archive":["Portico"],"relation":{"correction":[{"id-type":"doi","id":"10.1002\/ppul.24291","asserted-by":"object"}]},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,14]]}}}