{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:00:05Z","timestamp":1785297605544,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T00:00:00Z","timestamp":1480291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"none reported"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Cystic fibrosis (CF) patients almost regularly reveal sinonasal pathology. The purpose of this study was to assess association between objective and subjective measurements of sinonasal involvement comparing nasal airflow obtained by active anterior rhinomanometry (AAR), nasal endoscopic findings, and symptoms assessed with the Sino\u2010Nasal Outcome Test\u201020 (SNOT\u201020).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nasal cavities were explored by anterior rigid rhinoscopy and findings were compared to inspiratory nasal airflow measured by AAR to quantify nasal patency and subjective health\u2010related quality of life in sinonasal disease obtained with the SNOT\u201020 questionnaire. Relations to upper and lower airway colonization with <jats:italic>Pseudomonas aeruginosa<\/jats:italic>, medical treatment, and sinonasal surgery were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 124 CF patients were enrolled (mean age 19.9\u2009\u00b1\u200910.4 years, range 4\u201365 years). A significant association of detection of nasal polyposis (NP) in rhinoscopy was found with increased primary nasal symptoms (PNS) which include \u201cnasal obstruction,\u201d \u201csneezing,\u201d \u201crunny nose,\u201d \u201cthick nasal discharge,\u201d and \u201creduced sense of smell.\u201d At the same time patients with pathologically decreased airflow neither showed elevated SNOT\u201020 scores nor abnormal rhinoscopic findings. Altogether, rhinomanometric and rhinoscopic findings are not significantly related.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among SNOT\u201020 scores the PNS subscore is related to rhinoscopically detected polyposis and sinonasal secretion. Therefore, we recommend including short questions regarding PNS into CF\u2010routine care. At the same time our results show that a high inspiratory airflow is not associated with a good sensation of nasal patency. Altogether, rhinomanometry is not required within routine CF\u2010care, but it can be interesting as an outcome parameter within clinical trials. <jats:bold>Pediatr Pulmonol. 2017;52:167\u2013174.<\/jats:bold> \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.23613","type":"journal-article","created":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T16:12:25Z","timestamp":1480349545000},"page":"167-174","source":"Crossref","is-referenced-by-count":19,"title":["Importance to question sinonasal symptoms and to perform rhinoscopy and rhinomanometry in cystic fibrosis patients"],"prefix":"10.1002","volume":"52","author":[{"given":"J.M.","family":"Bock","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Cystic Fibrosis Centre Jena University Hospital Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Schien","sequence":"additional","affiliation":[{"name":"Surgical and Perioperative Sciences 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