{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T13:21:46Z","timestamp":1782566506805,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,10,31]],"date-time":"2016-10-31T00:00:00Z","timestamp":1477872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"none reported"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Childhood sarcoidosis is a very rare granulomatous disorder with an unknown etiology. Stage 1 disease is the most common whereas stages 2, 3, and 0 are rare in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate thoracic findings of pediatric pulmonary sarcoidosis on MRI and to compare them with CT findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between August 2010 and May 2015, seven consecutive pediatric patients (four male, three female; age range: 8\u201318 years, mean age: 13.5\u2009\u00b1\u20093.01 years) who were diagnosed with sarcoidosis were enrolled in our study prospectively. Inclusion criterion was patients with stages 1\u20134 sarcoidosis who underwent contrast enhanced chest CT for initial diagnosis or follow\u2010up evaluation of thoracic findings and exclusion criteria were patients with stage 0 disease with extra\u2010pulmonary manifestations (n\u2009=\u20094).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two patients who recovered from stage 2 to stage 0 were interpreted as normal. Five patients had abnormal findings on chest CT, including hilar\/mediastinal lymphadenopathy (n\u2009=\u20095, 71%), nodules larger than 3\u2009mm (n\u2009=\u20094, 57%), ground glass opacity (n\u2009=\u20094, 57%), thickening of the pleura\/fissure (n\u2009=\u20093, 42%), interlobular septal thickening (n\u2009=\u20092, 28%), atelectasis (n\u2009=\u20091, 14%), consolidation (n\u2009=\u20091, 14%), bronchiectasis (n\u2009=\u20091, 14%), intraparenchymal and subpleural cysts (n\u2009=\u20091,14%), fibrotic bands (n\u2009=\u20091, 14%), and enlarged pulmonary artery (n\u2009=\u20091, 14%). Findings that were detected on CT but not observed by lung MRI were nodules &lt;3\u2009mm (n\u2009=\u20094, 57%), mild bronchiectasis and mild ground glass opacity (n\u2009=\u20091, 14%), and subpleural and intraparenchymal cysts (n\u2009=\u20091, 14%). The sensitivity and specificity of MRI were 85.2% and 100%, respectively. There was no statistically significant difference between lung MRI and CT in detecting the thoracic findings in stages 1, 2, and 4 sarcoidosis (<jats:italic>P<\/jats:italic>\u2009=\u20090.1336, 95%Cl).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Contrast\u2010enhanced lung MRI with fast imaging sequences is a highly sensitive imaging modality and comparable with CT in evaluating both lung and cardiac abnormalities in pediatric sarcoidosis. Given there is no associated ionizing radiation, chest MRI is a promising imaging modality in this pediatric patient population. <jats:bold>Pediatr Pulmonol. 2017;52:494\u2013499.<\/jats:bold> \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.23614","type":"journal-article","created":{"date-parts":[[2016,10,31]],"date-time":"2016-10-31T12:38:43Z","timestamp":1477917523000},"page":"494-499","source":"Crossref","is-referenced-by-count":25,"title":["Thoracic MRI evaluation of sarcoidosis in children"],"prefix":"10.1002","volume":"52","author":[{"given":"Sureyya Burcu","family":"Gorkem","sequence":"first","affiliation":[{"name":"Pediatric Radiology Section Department of Radiology Erciyes University School of Medicine Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se\u00e7il","family":"K\u00f6se","sequence":"additional","affiliation":[{"name":"Kayseri E\u011fitim ve Arast\u0131rma Hastanesi Erkilet \u00c7ocuk Hastanesi Pediatri B\u00f6l\u00fcm\u00fc Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Departments of Radiology and Medicine, Pulmonary Division Boston Children's Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selim","family":"Do\u011fanay","sequence":"additional","affiliation":[{"name":"Pediatric Radiology Section Department of Radiology Erciyes University School of Medicine Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse Seda","family":"Coskun","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Erciyes University School of Medicine Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"K\u00f6se","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology Department of Pediatrics Erciyes University School of Medicine Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,31]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"149","article-title":"Sarcoidosis in children","volume":"30","author":"Shetty AK","year":"2000","journal-title":"Curr Probl Pediatr"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2004.tb00670.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2005.03.007"},{"key":"e_1_2_5_5_1","first-page":"6","article-title":"Childhood sarcoidosis: a rare but fascinating disorder","volume":"23","author":"Shetty AK","year":"2008","journal-title":"Pediatr Rheumatol Online J"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.2.ats4-99"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22956"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.2710"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-002-1404-4"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2008.05.017"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.12.9502"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1258\/ar.2011.100429"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25082"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2011.02067.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-11-243"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2462070712"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/RTI.0b013e3182a4378b"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200505-810OC"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2013.08.019"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcv200"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1102\/1470-7330.2008.0018"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mric.2008.02.014"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.4.1173"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199403000-00012"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.2833"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2261011974"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10033"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1258\/ar.2011.110445"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.23614","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.23614","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.23614","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.23614","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.23614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T09:05:24Z","timestamp":1693991124000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.23614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,31]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1002\/ppul.23614"],"URL":"https:\/\/doi.org\/10.1002\/ppul.23614","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,31]]}}}