{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:35:52Z","timestamp":1792708552636,"version":"4.5.0"},"reference-count":64,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T00:00:00Z","timestamp":1479686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006501","name":"Cystic Fibrosis Foundation Therapeutics","doi-asserted-by":"publisher","award":["THORNTO7XX0"],"award-info":[{"award-number":["THORNTO7XX0"]}],"id":[{"id":"10.13039\/100006501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006662","name":"National Institute on Handicapped Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006662","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:label\/><jats:p>The prevalence of aspergillosis in CF patients has until recently been underestimated, but increasing evidence suggests that it may play an important role in the progression of CF lung disease. In healthy airways, <jats:italic>Aspergillus fumigatus<\/jats:italic> can be efficiently removed from the lung by mechanisms such as mucociliary clearance and cough. However, these mechanisms are defective in CF, allowing pathogens such as <jats:italic>A. fumigatus<\/jats:italic> to germinate and establish chronic infections within the airways. The precise means by which <jats:italic>A. fumigatus<\/jats:italic> contributes to CF lung disease remain largely unclear. As the first point of contact within the lung, and an important component of the innate immune system, it is likely that the mucus barrier plays an important role in this process. Study of the functional interplay between this vital protective barrier, and in particular its principal structural components, the polymeric gel\u2010forming mucins, and CF pathogens such as <jats:italic>A. fumigatus<\/jats:italic>, is at an early stage. <jats:italic>A. fumigatus<\/jats:italic> protease activity has been shown to upregulate mucus production by inducing mucin mRNA and protein expression, and <jats:italic>A. fumigatus<\/jats:italic> proteases and glycosidases are able to degrade mucins. This may allow <jats:italic>A. fumigatus<\/jats:italic> to alter mucus barrier properties to promote fungal colonization of the airways and\/or utilize mucins as a nutrient source. Moreover, conidial surface lectin binding to mucin glycans is a key aspect of clearance of <jats:italic>Aspergillus<\/jats:italic> from the lung in health but may be an important aspect of colonization, where mucociliary clearance is compromised, as in the CF lung. Here we discuss the nature of the mucus barrier and its mucin components in CF, and how they may be implicated in <jats:italic>A. fumigatus<\/jats:italic> infection. <jats:bold>Pediatr Pulmonol 2017;52:548\u2013555.<\/jats:bold> \u00a9 2016 The Authors. Pediatric Pulmonology. Published by Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.23618","type":"journal-article","created":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T16:43:55Z","timestamp":1479746635000},"page":"548-555","source":"Crossref","is-referenced-by-count":33,"title":["Aspergillosis and the role of mucins in cystic fibrosis"],"prefix":"10.1002","volume":"52","author":[{"given":"Abigail C.","family":"Cowley","sequence":"first","affiliation":[{"name":"Wellcome Trust Centre for Cell\u2010Matrix Research University of Manchester Manchester United Kingdom"},{"name":"Faculty of Biology, Medicine and Health, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences University of Manchester Manchester United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Thornton","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Cell\u2010Matrix Research University of Manchester Manchester 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