{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T22:50:14Z","timestamp":1779317414234,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,10,31]],"date-time":"2016-10-31T00:00:00Z","timestamp":1477872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"none reported"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Exercise\u2010induced laryngeal obstruction (EILO) may affect as many as 6% of the adolescent population, with some patients experiencing symptoms refractory to conservative interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This report describes therapeutic laryngoscopy during exercise, a novel, non\u2010surgical intervention that harnesses real\u2010time laryngoscopy video as biofeedback to control laryngeal aperture during high\u2010intensity exercise. Additionally, we quantitate patient\u2010reported perceptions of procedure safety, tolerability, learning value, and effectiveness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical EILO patients with symptoms refractory to conventional respiratory retraining and other therapies were referred for the procedure which features laryngoscopy video as biofeedback during serial physician\u2010guided 1\u2010min exercise sprints. We quantify perceptions of procedure safety, tolerability, learning value, and effectiveness through questionnaires offered to all patients as well as observers of the procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010one patients and 37 parent observers were approached for feedback; 88% of patients and 95% of observers consented to participation. Patients and observers reported perceptions of safety and tolerability (81% and 86%, respectively), learning value (78% and 91%, respectively), and effectiveness (58% and 80%, respectively) with patient age predicting some responses. Seventy\u2010five percent of patients noted that \u201cSince the procedure, my breathing during exercise has improved,\u201d and 85% of this group noted that therapeutic laryngoscopy during exercise was \u201cthe most important therapy leading to my breathing improvement.\u201d The procedure also provided insight into the psychological experience of patients, a domain not clinically apparent prior to the procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data support further study of therapeutic laryngoscopy during exercise as a possible intervention for patients with refractory EILO. <jats:bold>Pediatr Pulmonol. 2017;52:813\u2013819.<\/jats:bold> \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.23634","type":"journal-article","created":{"date-parts":[[2016,10,31]],"date-time":"2016-10-31T13:14:56Z","timestamp":1477919696000},"page":"813-819","source":"Crossref","is-referenced-by-count":41,"title":["Therapeutic laryngoscopy during exercise: A novel non\u2010surgical therapy for refractory EILO"],"prefix":"10.1002","volume":"52","author":[{"given":"J. Tod","family":"Olin","sequence":"first","affiliation":[{"name":"Department of Pediatrics National Jewish Health 1400 Jackson Street Denver Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily H.","family":"Deardorff","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine National Jewish Health Denver Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth M.","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Jewish Health 1400 Jackson Street Denver Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina L.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine National Jewish Health Denver Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie L.","family":"Keever","sequence":"additional","affiliation":[{"name":"Pulmonary Physiology Services National Jewish Health Denver Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille M.","family":"Moore","sequence":"additional","affiliation":[{"name":"Division of Biostatistics &amp; Bioinformatics National Jewish Health Denver Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce G.","family":"Bender","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Jewish Health 1400 Jackson Street Denver Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.00006513"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.3.8630577"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-205738"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198306303082605"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1064038"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61341-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-006-0216-6"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.4.7551399"},{"key":"e_1_2_8_10_1","first-page":"823","article-title":"Validation of the dyspnea index in adolescents with exercise\u2010induced paradoxical vocal fold motion","volume":"140","author":"De Guzman V","year":"2014","journal-title":"JAMA"},{"key":"e_1_2_8_11_1","first-page":"1152","article-title":"Surgical treatment is effective in severe cases of exercise\u2010induced laryngeal obstruction: a follow\u2010up study","volume":"135","author":"Norlander K","year":"2015","journal-title":"Acta Otolaryngol"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-205773"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1249\/00003677-198800160-00015"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198711000-00019"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000184528.16229.ba"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24812"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00160-2016"},{"key":"e_1_2_8_18_1","volume-title":"R: A Language and environment for statistical computing","year":"2015"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2013.12.017"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12550"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.23634","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.23634","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.23634","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:39:23Z","timestamp":1696379963000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.23634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,31]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1002\/ppul.23634"],"URL":"https:\/\/doi.org\/10.1002\/ppul.23634","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,31]]}}}