{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:52:28Z","timestamp":1786978348345,"version":"build-2736575974"},"reference-count":9,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T00:00:00Z","timestamp":1485734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NHLBI RO1 HL\u201061007"],"award-info":[{"award-number":["NHLBI RO1 HL\u201061007"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      During the Fall of 2014, numerous children were hospitalized with asthma or respiratory distress related to Enterovirus D68 (EV\u2010D68). A large proportion initially tested positive for rhinovirus. During this period our laboratory noted a cross\u2010reactivity between EV\u2010D68 and the rhinovirus component of the GenMark multiplex respiratory viral panel. Many other laboratories used assays not designed to distinguish these\n                      <jats:italic>Picornoviridae<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To compare the presentation and outcomes of patients with rhinovirus and EV\u2010D68, 103 GenMark rhinovirus positive nasopharyngeal swabs from hospitalized children were retested for EV\u2010D68.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      EV\u2010D68 positive patients versus EV\u2010D68 negative patients were more likely to have a history of asthma (33.3% vs. 11.0%,\n                      <jats:italic>P\u2009=\u2009<\/jats:italic>\n                      0.02) and to present with acute respiratory illness (66.7% vs. 40.2%,\n                      <jats:italic>P\u2009=\u2009<\/jats:italic>\n                      0.048), especially status asthmaticus (47.6% vs. 2.4%,\n                      <jats:italic>P\u2009&lt;\u2009<\/jats:italic>\n                      0.001). On admission they had more wheezing, respiratory distress, and lower respiratory tract involvement, and were more likely to be treated with steroids and discharged home on asthma medications. Respiratory viral coinfection was less common in EV\u2010D68 positive vs EV\u2010D68 negative patients. In patients without a respiratory viral coinfection the overall findings were similar.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Patients with EV\u2010D68 versus rhinovirus were more likely to have a history of asthma, to present with status asthmaticus, to wheeze on admission, and to receive treatment with asthma medications in hospital and at discharge. The inability of common assays to distinguish EV\u2010D68 from rhinoviruses raises the possibility that the role of EV\u2010D68 as a viral trigger of asthma has been under appreciated.\n                      <jats:bold>Pediatr Pulmonol. 2017;52:827\u2013832.<\/jats:bold>\n                      \u00a9 2017 Wiley Periodicals, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.23661","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T11:22:56Z","timestamp":1485775376000},"page":"827-832","source":"Crossref","is-referenced-by-count":19,"title":["A comparison of hospitalized children with enterovirus D68 to those with rhinovirus"],"prefix":"10.1002","volume":"52","author":[{"given":"Charles B.","family":"Foster","sequence":"first","affiliation":[{"name":"Center for Pediatric Infectious Diseases Cleveland Clinic Children's Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritika","family":"Coelho","sequence":"additional","affiliation":[{"name":"Center for Pediatric Infectious Diseases Cleveland Clinic Children's Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Brown","sequence":"additional","affiliation":[{"name":"Center for Pediatric Research Cleveland Clinic Children's Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aman","family":"Wadhwa","sequence":"additional","affiliation":[{"name":"Center for Pediatric Infectious Diseases Cleveland Clinic Children's Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amena","family":"Dossul","sequence":"additional","affiliation":[{"name":"Center for Pediatric Infectious Diseases Cleveland Clinic Children's Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca E.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Center for Pediatric Infectious Diseases Cleveland Clinic Children's Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Cardenas","sequence":"additional","affiliation":[{"name":"Center for Pediatric Pulmonary Medicine Cleveland Clinic Children's Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Sabella","sequence":"additional","affiliation":[{"name":"Center for Pediatric Infectious Diseases Cleveland Clinic Children's Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie","family":"Kohn","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Cleveland Clinic Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherilynn","family":"Vogel","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Cleveland Clinic Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda","family":"Yen\u2010Lieberman","sequence":"additional","affiliation":[{"name":"Center for Pediatric Research Cleveland Clinic Children's Cleveland Ohio"},{"name":"Department of Laboratory Medicine Cleveland Clinic Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Piedimonte","sequence":"additional","affiliation":[{"name":"Center for Pediatric Research Cleveland Clinic Children's Cleveland Ohio"},{"name":"Center for Pediatric Pulmonary Medicine Cleveland Clinic Children's Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00335-5"},{"key":"e_1_2_6_3_1","first-page":"798","article-title":"Severe respiratory illness associated with enterovirus d68\u2014missouri and illinois, 2014","volume":"63","author":"Midgley CM","year":"2014","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118529"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02290-09"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00542-06"},{"key":"e_1_2_6_7_1","unstructured":"Enterovirus D68 2014 Real\u2010Time RT\u2010PCR Assay Centers for Disease Control and Prevention. 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