{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:44:16Z","timestamp":1790876656169,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T00:00:00Z","timestamp":1484265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"none reported"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The object of this study was to determine whether high doses of inhaled budesonide provide additional benefits to a standardized treatment regimen that includes systemic steroids and salbutamol in preschool patients presented to the emergency department (ED) with acute wheezing attacks. Methods This randomized, double\u2010blind, placebo\u2010controlled, parallel group trial was conducted in children, 6 months\u20136 years with moderate or severe acute wheezing epizode, as determined based on a pulmonary index score (PIS) of 7\u201313 points. We compared the addition of budesonide 3\u2009mg versus placebo to standard acute asthma treatment, which included salbutamol and a single 1\u2009mg\/kg dose of methylprednisolone given at the beginning of therapy. The primary outcome was differences in hospitalization rates within 4\u2009hr. Secondary outcome was difference in median PIS between treatment groups at 2\u2009hr. Results One hundred patients were enrolled. Cumulative hospitalization rate at 120, 180, and 240\u2009min were 0.72, 0.62, and 0.58 in placebo group; and 0.44, 0.30, and 0.24 in budesonide group. Discharged rate in budesonide group was significantly higher than the placebo group (log\u2010rank\u2009=\u200912.407 ve <jats:italic>P\u2009<\/jats:italic>&lt;\u20090.001). Expected mean discharged times were 200.4 (95%CI\u2009=\u2009185.3\u2013215.5)\u2009min in placebo group and 164.4 (95%CI\u2009=\u2009149.4\u2013179.4)\u2009min in budesonide group. Median (25\u201375%) PIS at the 120th min was significantly lower in budesonide group than the placebo group (5 [4\u20138] vs. 8 [5\u20139] respectively, <jats:italic>P<\/jats:italic>\u2009=\u20090.006). Conclusions The addition of budesonide nebulization may decrease the admission rate of preschool children who have moderate to severe acute wheezing epizodes. <jats:bold>Pediatr Pulmonol. 2017;52:720\u2013728.<\/jats:bold> \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.23667","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T22:10:11Z","timestamp":1484345411000},"page":"720-728","source":"Crossref","is-referenced-by-count":11,"title":["Budesonide reduces hospital admission rates in preschool children with acute wheezing"],"prefix":"10.1002","volume":"52","author":[{"given":"Cem Hasan","family":"Razi","sequence":"first","affiliation":[{"name":"Division of Pediatric Allergy Ac\u0131badem  Ankara Private Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazl\u0131","family":"C\u00f6r\u00fct","sequence":"additional","affiliation":[{"name":"Division of Pediatric Allergy Department of Pediatrics Sami Ulus Pediatrics and Gynecology Education and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesibe","family":"And\u0131ran","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kecioren Education and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpem.2004.09.002"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1542\/peds.92.4.513","article-title":"Controlled trial of oral prednisone in the emergency deparment treatment of children with acute asthma","volume":"92","author":"Scarfone 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